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A human acute T lymphoblastic leukemia line (PF-382) was serially transplanted into nude mice. No takes were observed in untreated nude mice, whereas solid tumors were observed in splenectomized and total body, sublethally irradiated mice. The minimal tumor-inducing dose and the latency time remained unchanged after the third and fifth serial transplants. Moreover, leukemic cells recovered from the 8th in vivo passages displayed the same differentiation antigens and chromosomal markers as the in vitro PF-382 cell line used for the first transplant. This stable and well-characterized experimental system could be a new model for T-lymphocyte differentiation and immune-reactivity against human leukemias.
M G Martinotti, and
R Arione, and
R Foà, and
L Pegoraro, and
C Jemma, and
G Forni
July 1981,
British journal of cancer,
M G Martinotti, and
R Arione, and
R Foà, and
L Pegoraro, and
C Jemma, and
G Forni
June 1989,
International journal of cancer,
M G Martinotti, and
R Arione, and
R Foà, and
L Pegoraro, and
C Jemma, and
G Forni
May 1982,
British journal of cancer,
M G Martinotti, and
R Arione, and
R Foà, and
L Pegoraro, and
C Jemma, and
G Forni
January 2011,
In vivo (Athens, Greece),
M G Martinotti, and
R Arione, and
R Foà, and
L Pegoraro, and
C Jemma, and
G Forni
October 1987,
Tumori,
M G Martinotti, and
R Arione, and
R Foà, and
L Pegoraro, and
C Jemma, and
G Forni
October 1977,
British journal of cancer,
M G Martinotti, and
R Arione, and
R Foà, and
L Pegoraro, and
C Jemma, and
G Forni
December 1982,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
M G Martinotti, and
R Arione, and
R Foà, and
L Pegoraro, and
C Jemma, and
G Forni
September 1996,
Japanese journal of cancer research : Gann,
M G Martinotti, and
R Arione, and
R Foà, and
L Pegoraro, and
C Jemma, and
G Forni
March 1979,
Journal of the National Cancer Institute,
M G Martinotti, and
R Arione, and
R Foà, and
L Pegoraro, and
C Jemma, and
G Forni
June 1968,
Cancer research,
