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OKT3 monoclonal antibody is a murine monoclonal antibody specific for the T lymphocyte T3 cell surface receptor that mediates antigen recognition. The use of OKT3 monoclonal antibody for the treatment of cardiac allograft rejection refractory to conventional therapy with high-dose steroids and antithymocyte globulin is described. Seven patients received 5 mg of OKT3 monoclonal antibody intravenously per day for 10 to 14 days. Diagnosis of moderate or severe rejection was made in all seven from right ventricular endomyocardial biopsy. Biopsy was repeated 48 to 72 hours and seven to 10 days after OKT3 monoclonal antibody was begun. With treatment, four patients had a complete response, with improvement on both early and late biopsy. Two patients had partial responses, with improvement on early biopsy followed by worsening rejection on late biopsy. One patient died of graft failure six hours after receiving OKT3 monoclonal antibody. Adverse events were common in the first two days of therapy but were well tolerated. It is concluded that OKT3 monoclonal antibody is useful in the treatment of refractory cardiac allograft rejection.
E M Gilbert, and
C W Dewitt, and
C C Eiswirth, and
D G Renlund, and
R L Menlove, and
L A Freedman, and
C M Herrick, and
W A Gay, and
M R Bristow
December 1981,
Transplantation,
E M Gilbert, and
C W Dewitt, and
C C Eiswirth, and
D G Renlund, and
R L Menlove, and
L A Freedman, and
C M Herrick, and
W A Gay, and
M R Bristow
April 1988,
Transplantation,
E M Gilbert, and
C W Dewitt, and
C C Eiswirth, and
D G Renlund, and
R L Menlove, and
L A Freedman, and
C M Herrick, and
W A Gay, and
M R Bristow
January 1993,
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
E M Gilbert, and
C W Dewitt, and
C C Eiswirth, and
D G Renlund, and
R L Menlove, and
L A Freedman, and
C M Herrick, and
W A Gay, and
M R Bristow
January 1987,
Pharmacotherapy,
E M Gilbert, and
C W Dewitt, and
C C Eiswirth, and
D G Renlund, and
R L Menlove, and
L A Freedman, and
C M Herrick, and
W A Gay, and
M R Bristow
January 1990,
The Journal of heart transplantation,
E M Gilbert, and
C W Dewitt, and
C C Eiswirth, and
D G Renlund, and
R L Menlove, and
L A Freedman, and
C M Herrick, and
W A Gay, and
M R Bristow
April 1997,
Zhonghua wai ke za zhi [Chinese journal of surgery],
E M Gilbert, and
C W Dewitt, and
C C Eiswirth, and
D G Renlund, and
R L Menlove, and
L A Freedman, and
C M Herrick, and
W A Gay, and
M R Bristow
January 1993,
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
E M Gilbert, and
C W Dewitt, and
C C Eiswirth, and
D G Renlund, and
R L Menlove, and
L A Freedman, and
C M Herrick, and
W A Gay, and
M R Bristow
December 1989,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
E M Gilbert, and
C W Dewitt, and
C C Eiswirth, and
D G Renlund, and
R L Menlove, and
L A Freedman, and
C M Herrick, and
W A Gay, and
M R Bristow
May 1989,
Transplantation,
E M Gilbert, and
C W Dewitt, and
C C Eiswirth, and
D G Renlund, and
R L Menlove, and
L A Freedman, and
C M Herrick, and
W A Gay, and
M R Bristow
December 1984,
Transplantation,
