Association between migraine and risk of stroke: a systematic review and meta-analysis. 2022

Shuyuan Zhang, and Haixuan Liu, and Tingwen Shi
Department of Acupuncture, Beijing Huguosi Traditional Chinese Medicine Hospital, affiliated to Beijing University of Chinese Medicine, No. 83 Mianhua Hutong, Xicheng District, Beijing, 100035, China. shu72yuanzhang1_1@126.com.

BACKGROUND Results regarding the association between migraine and risk of stroke are inconsistent. METHODS A literature search of the databases (Web of Science, Google Scholar and PubMed) was made before December 2021. STATA 12.0 software was used. Odds ratios (ORs) or relative risks (RRs) and their 95% confidence intervals (CIs) regarding migraine and risk of stroke were computed. RESULTS Migraine was associated with increased risks of total stroke, ischemic stroke (IS) and haemorrhagic stroke (HS) (total stroke: OR/RR = 1.62; 95% CI: 1.44-1.83, I2 = 95.8%, p < 0.001; IS: OR/RR = 1.70; 95% CI: 1.47-1.98, I2 = 96.1%, p < 0.001; HS: OR/RR = 1.35; 95% CI: 1.11-1.63, I2 = 85.7%, p < 0.001). Migraine with aura was related to increased risks of total stroke, IS and HS (total stroke: OR/RR = 1.95; 95% CI: 1.62-2.34, I2 = 89.7%, p < 0.001; IS: OR/RR = 2.17; 95% CI: 1.78-2.64, I2 = 89.2%, p < 0.001; HS: OR/RR = 1.30; 95% CI: 1.04-1.62, I2 = 46.3%, p = 0.114). Migraine without aura was related to increased risks of total stroke, IS and HS (total stroke: OR/RR = 1.35; 95% CI: 1.18-1.55, I2 = 85.4%, p < 0.001; IS: OR/RR = 1.34; 95% CI: 1.11-1.62, I2 = 87.8%, p < 0.001; HS: OR/RR = 1.29; 95% CI: 1.04-1.61, I2 = 64.8%, p = 0.023). CONCLUSIONS Migraine is associated with a higher risk of total stroke and IS. However, the association between migraine and risk of HS is with more uncertainty.

UI MeSH Term Description Entries
D008881 Migraine Disorders A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1) Acute Confusional Migraine,Headache, Migraine,Status Migrainosus,Abdominal Migraine,Cervical Migraine Syndrome,Hemicrania Migraine,Migraine,Migraine Headache,Migraine Variant,Sick Headache,Abdominal Migraines,Acute Confusional Migraines,Cervical Migraine Syndromes,Disorder, Migraine,Disorders, Migraine,Headache, Sick,Headaches, Migraine,Headaches, Sick,Hemicrania Migraines,Migraine Disorder,Migraine Headaches,Migraine Syndrome, Cervical,Migraine Syndromes, Cervical,Migraine Variants,Migraine, Abdominal,Migraine, Acute Confusional,Migraine, Hemicrania,Migraines,Migraines, Abdominal,Migraines, Acute Confusional,Migraines, Hemicrania,Sick Headaches,Variant, Migraine,Variants, Migraine
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000083242 Ischemic Stroke Stroke due to BRAIN ISCHEMIA resulting in interruption or reduction of blood flow to a part of the brain. When obstruction is due to a BLOOD CLOT formed within in a cerebral blood vessel it is a thrombotic stroke. When obstruction is formed elsewhere and moved to block a cerebral blood vessel (see CEREBRAL EMBOLISM) it is referred to as embolic stroke. Wake-up stroke refers to ischemic stroke occurring during sleep while cryptogenic stroke refers to ischemic stroke of unknown origin. Acute Ischemic Stroke,Cryptogenic Embolism Stroke,Cryptogenic Ischemic Stroke,Cryptogenic Stroke,Ischaemic Stroke,Wake-up Stroke,Acute Ischemic Strokes,Cryptogenic Embolism Strokes,Cryptogenic Ischemic Strokes,Cryptogenic Strokes,Embolism Stroke, Cryptogenic,Ischaemic Strokes,Ischemic Stroke, Acute,Ischemic Stroke, Cryptogenic,Ischemic Strokes,Stroke, Acute Ischemic,Stroke, Cryptogenic,Stroke, Cryptogenic Embolism,Stroke, Cryptogenic Ischemic,Stroke, Ischaemic,Stroke, Ischemic,Stroke, Wake-up,Wake up Stroke,Wake-up Strokes
D000083302 Hemorrhagic Stroke Stroke due to rupture of a weakened blood vessel in the brain (e.g., CEREBRAL HEMISPHERES; CEREBELLUM; SUBARACHNOID SPACE). Intracerebral Hemorrhage Stroke,Intracerebral Hemorrhagic Stroke,Subarachnoid Hemorrhagic Stroke,Hemorrhage Stroke, Intracerebral,Hemorrhagic Stroke, Intracerebral,Hemorrhagic Stroke, Subarachnoid,Hemorrhagic Strokes,Intracerebral Hemorrhage Strokes,Intracerebral Hemorrhagic Strokes,Stroke, Hemorrhagic,Stroke, Intracerebral Hemorrhage,Stroke, Intracerebral Hemorrhagic,Stroke, Subarachnoid Hemorrhagic,Subarachnoid Hemorrhagic Strokes
D012306 Risk The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome. Relative Risk,Relative Risks,Risk, Relative,Risks,Risks, Relative
D012307 Risk Factors An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D016017 Odds Ratio The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases. Cross-Product Ratio,Risk Ratio,Relative Odds,Cross Product Ratio,Cross-Product Ratios,Odds Ratios,Odds, Relative,Ratio, Cross-Product,Ratio, Risk,Ratios, Cross-Product,Ratios, Risk,Risk Ratios
D020521 Stroke A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810) Apoplexy,Cerebral Stroke,Cerebrovascular Accident,Cerebrovascular Apoplexy,Vascular Accident, Brain,CVA (Cerebrovascular Accident),Cerebrovascular Accident, Acute,Cerebrovascular Stroke,Stroke, Acute,Acute Cerebrovascular Accident,Acute Cerebrovascular Accidents,Acute Stroke,Acute Strokes,Apoplexy, Cerebrovascular,Brain Vascular Accident,Brain Vascular Accidents,CVAs (Cerebrovascular Accident),Cerebral Strokes,Cerebrovascular Accidents,Cerebrovascular Accidents, Acute,Cerebrovascular Strokes,Stroke, Cerebral,Stroke, Cerebrovascular,Strokes,Strokes, Acute,Strokes, Cerebral,Strokes, Cerebrovascular,Vascular Accidents, Brain

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