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The effect of continuous subcutaneous insulin infusion (CSII) on glycaemic control and insulin binding to erythrocytes was studied in six diabetic patients. A marked improvement in blood glucose control during CSII was observed in these patients previously on conventional therapy. Specific 125I-insulin binding to erythrocytes of the diabetics before the institution of CSII was significantly lower than that of age-, weight- and sex-matched nondiabetic subjects, 6.5 +/- 0.1% vs. 9.8 +/- 0.3% (P less than 0.05). After 4-6 months of CSII, insulin binding was restored to normal levels. This normalization in insulin binding to erythrocytes of patients on CSII was due to a 35% increase in active binding sites, together with a small change in binding affinity.
F M Ng, and
E Babacan, and
M Cohen, and
P Z Zimmet
January 1984,
Clinical and investigative medicine. Medecine clinique et experimentale,
F M Ng, and
E Babacan, and
M Cohen, and
P Z Zimmet
December 2004,
Pediatric diabetes,
F M Ng, and
E Babacan, and
M Cohen, and
P Z Zimmet
January 1980,
Diabetes care,
F M Ng, and
E Babacan, and
M Cohen, and
P Z Zimmet
April 2003,
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy,
F M Ng, and
E Babacan, and
M Cohen, and
P Z Zimmet
February 1988,
Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde,
F M Ng, and
E Babacan, and
M Cohen, and
P Z Zimmet
November 1988,
International journal of microcirculation, clinical and experimental,
F M Ng, and
E Babacan, and
M Cohen, and
P Z Zimmet
December 1998,
Diabetes & metabolism,
F M Ng, and
E Babacan, and
M Cohen, and
P Z Zimmet
March 1980,
Diabetes,
F M Ng, and
E Babacan, and
M Cohen, and
P Z Zimmet
November 1984,
Archives of disease in childhood,
F M Ng, and
E Babacan, and
M Cohen, and
P Z Zimmet
December 1983,
Tijdschrift voor kindergeneeskunde,
