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Prognosis of Indolent Adult T-Cell Leukemia/Lymphoma. 2022
Takuro Kameda, and
Kotaro Shide, and
Yuki Tahira, and
Masaaki Sekine, and
Seiichi Sato, and
Junzo Ishizaki, and
Masanori Takeuchi, and
Keiichi Akizuki, and
Ayako Kamiunten, and
Haruko Shimoda, and
Takanori Toyama, and
Kouichi Maeda, and
Kiyoshi Yamashita, and
Noriaki Kawano, and
Hiroshi Kawano, and
Tomonori Hidaka, and
Hideki Yamaguchi, and
Yoko Kubuki, and
Akira Kitanaka, and
Hitoshi Matsuoka, and
Kazuya Shimoda
Division of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan.
A retrospective chart survey of the clinical features of indolent adult T-cell leukemia/lymphoma (ATL) was conducted in the Miyazaki Prefecture, Japan. This study enrolled 24 smoldering-type ATLs, 10 favorable chronic-type ATLs, and 20 unfavorable chronic-type ATLs diagnosed between 2010 and 2018. Among them, 4, 3, and 10 progressed to acute-type ATLs during their clinical course. The median survival time (MST) in smoldering-type ATL and favorable chronic-type ATL was not reached, and their 4-year overall survival (OS) was 73% and 79%, respectively. Compared with this, the prognosis of unfavorable chronic-type ATL was poor. Its MST was 3.32 years, and the 4-year OS was 46% (p = 0.0095). In addition to the three features that determine the unfavorable characteristics of chronic-type ATL, namely, increased lactate dehydrogenase, increased blood urea nitrogen, and decreased albumin, the high-risk category by the indolent ATL-Prognostic Index, which was defined by an increment of soluble interleukin-2 receptor (sIL2-R) of >6000 U/mL, could explain the poor prognosis in indolent ATL patients. The level of sIL-2R might be an indicator of the initiation of therapy for indolent ATL.
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