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Following T cell-depleted bone marrow transplantation, helper T cell numbers remain depressed for some months. Nonetheless, functional B cells can be adoptively transferred to the recipients of such grafts, where they continue to secrete antibody. We now show that immunoglobulin production by these transferred B cells is induced by activated large granular lymphocytes (LGL) which circulate in the recipients in substantial numbers during the immediate post-transplant period. The LGL are CD3 negative and therefore provide help in an antigen-unlinked manner. Helper effects for autologous (donor) B cells are augmented by the addition of anti-LFA-2 (anti-CD2) which appears to act by blocking recruitment of LGL inhibitory to developing B cells. In contrast antibody to the beta chain of LFA-1, which effectively reduces natural killer activity of LGL, does not influence their helper function. The peripheral blood LGL fraction thus contains both helper and cytotoxic activity, which can be distinguished by appropriate monoclonal antibodies.
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A Vyakarnam, and
J E Reittie, and
J Z Wimperis, and
J P Grob, and
A V Hoffbrand, and
H G Prentice
September 1987,
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M K Brenner, and
A Vyakarnam, and
J E Reittie, and
J Z Wimperis, and
J P Grob, and
A V Hoffbrand, and
H G Prentice
May 1987,
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M K Brenner, and
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H G Prentice
December 2001,
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M K Brenner, and
A Vyakarnam, and
J E Reittie, and
J Z Wimperis, and
J P Grob, and
A V Hoffbrand, and
H G Prentice
March 1987,
British journal of haematology,
M K Brenner, and
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December 1997,
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H G Prentice
February 1993,
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M K Brenner, and
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A V Hoffbrand, and
H G Prentice
September 1986,
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M K Brenner, and
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H G Prentice
October 2003,
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M K Brenner, and
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H G Prentice
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M K Brenner, and
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H G Prentice
October 1978,
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