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The two nitropyridinium compounds tested sensitize hypoxic Serratia marcescens to irradiation up to the oxygen enhancement level by two components which can be separated as a function of compound concentration. Sensitization above the initial plateau level is in order of their determined one-electron reduction potentials, Ro 03-5580 (E 7 1 = -335 mV) being more efficient than Ro 03-5637 (E 7 1 = -358 mV). Additivity in sensitization up to a maximum enhancement level of 2.1 +/- 0.1 is found on combining these hydrophilic compounds at concentrations to give sensitization at the plateau level, with the hydrophobic sensitizer paranitroacetophenone (PNAP). It is concluded that the nitropyridinium compounds and PNAP sensitize the same site.
R F Anderson, and
K B Patel, and
C E Smithen
March 1976,
Radiology,
R F Anderson, and
K B Patel, and
C E Smithen
November 1997,
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R F Anderson, and
K B Patel, and
C E Smithen
October 1971,
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R F Anderson, and
K B Patel, and
C E Smithen
November 1981,
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R F Anderson, and
K B Patel, and
C E Smithen
January 1983,
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R F Anderson, and
K B Patel, and
C E Smithen
June 2010,
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R F Anderson, and
K B Patel, and
C E Smithen
August 1979,
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R F Anderson, and
K B Patel, and
C E Smithen
February 1968,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
R F Anderson, and
K B Patel, and
C E Smithen
June 1956,
Canadian journal of microbiology,
R F Anderson, and
K B Patel, and
C E Smithen
October 1972,
The Medical annals of the District of Columbia,
