Longitudinally extensive dorsal column spinal cord lesion with sensory ganglionopathy. 2022

Ylec M Cardenas Castillo, and Adeel S Zubair, and Daniel DiCapua, and Idaira Aguila-Tejedor, and Uzma Usman
Department of Neurology, Division of Neuromuscular Medicine, Yale School of Medicine, New Haven, CT, USA.

We present a case of a 23-year-old woman with a history of celiac disease who presented with a 2-month history of progressive gait unsteadiness and falls. Neurologic examination exhibited preserved motor strength, diffuse areflexia, and ataxic gait. Autoimmune and infectious workups were unremarkable, including vitamin B12. Electrodiagnostic testing showed absent diffuse sensory responses, consistent with sensory ganglionopathy. Total spine magnetic resonance imaging (MRI) revealed a non-enhancing, posterior cord, hyperintense signal from C1-T11. Partial improvement in her sensory ataxia was noted after 6 months of high-dose steroids without dorsal cord signals change on repeat MRI that suggests Wallerian degeneration of sensory axons.

UI MeSH Term Description Entries
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D013116 Spinal Cord A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER. Coccygeal Cord,Conus Medullaris,Conus Terminalis,Lumbar Cord,Medulla Spinalis,Myelon,Sacral Cord,Thoracic Cord,Coccygeal Cords,Conus Medullari,Conus Terminali,Cord, Coccygeal,Cord, Lumbar,Cord, Sacral,Cord, Spinal,Cord, Thoracic,Cords, Coccygeal,Cords, Lumbar,Cords, Sacral,Cords, Spinal,Cords, Thoracic,Lumbar Cords,Medulla Spinali,Medullari, Conus,Medullaris, Conus,Myelons,Sacral Cords,Spinal Cords,Spinali, Medulla,Spinalis, Medulla,Terminali, Conus,Terminalis, Conus,Thoracic Cords
D013118 Spinal Cord Diseases Pathologic conditions which feature SPINAL CORD damage or dysfunction, including disorders involving the meninges and perimeningeal spaces surrounding the spinal cord. Traumatic injuries, vascular diseases, infections, and inflammatory/autoimmune processes may affect the spinal cord. Myelopathy,Spinal Cord Disorders,Myelopathies,Spinal Cord Disease,Spinal Cord Disorder
D014805 Vitamin B 12 A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12. Cobalamin,Cyanocobalamin,Cobalamins,Eritron,Vitamin B12,B 12, Vitamin,B12, Vitamin
D055815 Young Adult A person between 19 and 24 years of age. Adult, Young,Adults, Young,Young Adults
D020234 Gait Ataxia Impairment of the ability to coordinate the movements required for normal ambulation (WALKING) which may result from impairments of motor function or sensory feedback. This condition may be associated with BRAIN DISEASES (including CEREBELLAR DISEASES and BASAL GANGLIA DISEASES); SPINAL CORD DISEASES; or PERIPHERAL NERVOUS SYSTEM DISEASES. Ataxia of Gait,Cerebellar Gait,Cerebellar Gait Ataxia,Gait Ataxia, Sensory,Ataxia, Cerebellar Gait,Ataxia, Gait,Ataxia, Sensory Gait,Ataxias, Cerebellar Gait,Ataxias, Gait,Ataxias, Sensory Gait,Cerebellar Gait Ataxias,Cerebellar Gaits,Gait Ataxia, Cerebellar,Gait Ataxias,Gait Ataxias, Cerebellar,Gait Ataxias, Sensory,Gait, Cerebellar,Gaits, Cerebellar,Sensory Gait Ataxia,Sensory Gait Ataxias

Related Publications

Ylec M Cardenas Castillo, and Adeel S Zubair, and Daniel DiCapua, and Idaira Aguila-Tejedor, and Uzma Usman
January 2014, Rinsho shinkeigaku = Clinical neurology,
Ylec M Cardenas Castillo, and Adeel S Zubair, and Daniel DiCapua, and Idaira Aguila-Tejedor, and Uzma Usman
January 2011, Internal medicine (Tokyo, Japan),
Ylec M Cardenas Castillo, and Adeel S Zubair, and Daniel DiCapua, and Idaira Aguila-Tejedor, and Uzma Usman
October 2010, Rinsho shinkeigaku = Clinical neurology,
Ylec M Cardenas Castillo, and Adeel S Zubair, and Daniel DiCapua, and Idaira Aguila-Tejedor, and Uzma Usman
November 2014, Zhonghua yi xue za zhi,
Ylec M Cardenas Castillo, and Adeel S Zubair, and Daniel DiCapua, and Idaira Aguila-Tejedor, and Uzma Usman
November 2020, JAMA neurology,
Ylec M Cardenas Castillo, and Adeel S Zubair, and Daniel DiCapua, and Idaira Aguila-Tejedor, and Uzma Usman
February 2023, Acta neurologica Belgica,
Ylec M Cardenas Castillo, and Adeel S Zubair, and Daniel DiCapua, and Idaira Aguila-Tejedor, and Uzma Usman
January 2008, Rinsho shinkeigaku = Clinical neurology,
Ylec M Cardenas Castillo, and Adeel S Zubair, and Daniel DiCapua, and Idaira Aguila-Tejedor, and Uzma Usman
February 2015, Practical neurology,
Ylec M Cardenas Castillo, and Adeel S Zubair, and Daniel DiCapua, and Idaira Aguila-Tejedor, and Uzma Usman
January 2023, Internal medicine (Tokyo, Japan),
Ylec M Cardenas Castillo, and Adeel S Zubair, and Daniel DiCapua, and Idaira Aguila-Tejedor, and Uzma Usman
May 2016, Rinsho shinkeigaku = Clinical neurology,
Copied contents to your clipboard!