Norbert Wiener was the first to functionally define cybernetics as "the study of control and communication in the animal and the machine". Herein, it is shown that as a manifestation of physiology, cybernetics can be further reduced to cell-cell signaling to maintain homeostasis, bridging Newtonian 3rd Order Cybernetics with Quantum Mechanical 4th Order Cybernetics as our 'conversation with the Cosmos' based on Quantum Entanglement, constrained by non-localization. As such, cybernetics can be scientifically tested in toto from the functional to the metaphysical, rendered physical as communication for the first time. If that is correct, then the sooner we begin operating based on Quantum Mechanical principles, the sooner we will function based on predictive algorithms.