Sodium thiosulfate for prevention of cisplatin-induced hearing loss: updated survival from ACCL0431. 2022

Etan Orgel, and Doojduen Villaluna, and Mark D Krailo, and Adam Esbenshade, and Lillian Sung, and David R Freyer
Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA; Department of Pediatrics, University of Southern California, Los Angeles, CA, USA.

UI MeSH Term Description Entries
D002945 Cisplatin An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle. Platinum Diamminodichloride,cis-Diamminedichloroplatinum(II),cis-Dichlorodiammineplatinum(II),Biocisplatinum,Dichlorodiammineplatinum,NSC-119875,Platidiam,Platino,Platinol,cis-Diamminedichloroplatinum,cis-Platinum,Diamminodichloride, Platinum,cis Diamminedichloroplatinum,cis Platinum
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013885 Thiosulfates Inorganic salts of thiosulfuric acid possessing the general formula R2S2O3. Thiosulfate
D034381 Hearing Loss A general term for the complete or partial loss of the ability to hear from one or both ears. Deafness, Transitory,Hearing Impairment,Hearing Loss, Transitory,Hypoacusis,Transitory Hearing Loss,Deafnesses, Transitory,Hypoacuses,Loss, Hearing,Loss, Transitory Hearing,Transitory Deafness,Transitory Deafnesses,Transitory Hearing Losses

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