Sodium thiosulfate for prevention of cisplatin-induced hearing loss: updated survival from ACCL0431.
2022
Etan Orgel, and
Doojduen Villaluna, and
Mark D Krailo, and
Adam Esbenshade, and
Lillian Sung, and
David R Freyer
Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA; Department of Pediatrics, University of Southern California, Los Angeles, CA, USA.
UI
MeSH Term
Description
Entries
D002945
Cisplatin
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
June 2021,
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology,
Etan Orgel, and
Doojduen Villaluna, and
Mark D Krailo, and
Adam Esbenshade, and
Lillian Sung, and
David R Freyer