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Chemical constituents from Pterocarpus santalinus and their inhibitory effects on nitric oxide production. 2022
Jae Sang Han, and
Hye Ryeong Hong, and
Jun Gu Kim, and
Thi Phuong Linh Le, and
Yong Beom Cho, and
Mi Kyeong Lee, and
Bang Yeon Hwang
College of Pharmacy, Chungbuk National University, Cheongju 28610, Republic of Korea.
A tropolone (2) and an acorane sesquiterpene (3), along with twenty previously known compounds were isolated from the heartwood of Pterocarpus santalinus. The structure of the isolated compounds was elucidated via 1D and 2D NMR spectroscopy and HRESIMS analysis. The absolute configuration of 3 was determined by comparison of the experimental and calculated ECD data. All compounds were evaluated for their inhibitory effects against nitric oxide production in LPS-stimulated RAW 264.7 macrophages.
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