A case of septic arthritis and osteomyelitis of the wrist with group B beta-hemolytic streptococci in an adult is reported. Neonatal septic arthritis and osteomyelitis caused by this organism have been previously reported. While rare in the adult, sporadic cases of septic arthritis and osteomyelitis have been seen. The elderly patient with diabetes seems to be a high-risk patient. Underlying chronic arthritis may confuse or delay the diagnosis.