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Eleven laboratories from eight countries and four continents took part in a collaborative study to evaluate experimental procedures to be used in selecting the new standard reference rabies vaccine prepared in human diploid cell cultures. The following procedures were used : (a) the NIH potency test in mice, (b) the antibody binding technique (by either mouse inoculation or the tissue culture method), (c) virus-neutralizing antibody levels in mice used for the NIH test, and (d) antibody induction in human volunteers treated with vaccine alone and in combination with human rabies gamma globulin. The four methods used for determination of rabies antibodies were mouse inoculation, rapid fluorescent focus inhibition, plaque reduction and complement fixation techniques. All results were expressed in International Units as compared to the standard WHO serum and vaccine preparations. In general, a close correlation was noted in results from different laboratories, and it was recommended that the future rabies standard vaccine should be evaluated by three testing procedures, the NIH test, the antibody-binding technique, and antibody levels in mice used for the NIH test.
T J Wiktor, and
P Atanasiu, and
M Bahmanyar, and
K Boegel, and
J H Cox, and
A M Diaz, and
E A Fitzgerald, and
E Kuwert, and
R Netter, and
M Selimov, and
G Turner, and
G van Steenis
January 1978,
Developments in biological standardization,
T J Wiktor, and
P Atanasiu, and
M Bahmanyar, and
K Boegel, and
J H Cox, and
A M Diaz, and
E A Fitzgerald, and
E Kuwert, and
R Netter, and
M Selimov, and
G Turner, and
G van Steenis
January 1979,
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, Betriebshygiene, praventive Medizin,
T J Wiktor, and
P Atanasiu, and
M Bahmanyar, and
K Boegel, and
J H Cox, and
A M Diaz, and
E A Fitzgerald, and
E Kuwert, and
R Netter, and
M Selimov, and
G Turner, and
G van Steenis
January 1963,
Journal of the American Veterinary Medical Association,
T J Wiktor, and
P Atanasiu, and
M Bahmanyar, and
K Boegel, and
J H Cox, and
A M Diaz, and
E A Fitzgerald, and
E Kuwert, and
R Netter, and
M Selimov, and
G Turner, and
G van Steenis
March 1982,
The Journal of general virology,
T J Wiktor, and
P Atanasiu, and
M Bahmanyar, and
K Boegel, and
J H Cox, and
A M Diaz, and
E A Fitzgerald, and
E Kuwert, and
R Netter, and
M Selimov, and
G Turner, and
G van Steenis
September 1967,
Journal of immunology (Baltimore, Md. : 1950),
T J Wiktor, and
P Atanasiu, and
M Bahmanyar, and
K Boegel, and
J H Cox, and
A M Diaz, and
E A Fitzgerald, and
E Kuwert, and
R Netter, and
M Selimov, and
G Turner, and
G van Steenis
December 2001,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
T J Wiktor, and
P Atanasiu, and
M Bahmanyar, and
K Boegel, and
J H Cox, and
A M Diaz, and
E A Fitzgerald, and
E Kuwert, and
R Netter, and
M Selimov, and
G Turner, and
G van Steenis
January 1989,
ALTEX,
T J Wiktor, and
P Atanasiu, and
M Bahmanyar, and
K Boegel, and
J H Cox, and
A M Diaz, and
E A Fitzgerald, and
E Kuwert, and
R Netter, and
M Selimov, and
G Turner, and
G van Steenis
January 1986,
Developments in biological standardization,
T J Wiktor, and
P Atanasiu, and
M Bahmanyar, and
K Boegel, and
J H Cox, and
A M Diaz, and
E A Fitzgerald, and
E Kuwert, and
R Netter, and
M Selimov, and
G Turner, and
G van Steenis
May 1950,
Harefuah,
T J Wiktor, and
P Atanasiu, and
M Bahmanyar, and
K Boegel, and
J H Cox, and
A M Diaz, and
E A Fitzgerald, and
E Kuwert, and
R Netter, and
M Selimov, and
G Turner, and
G van Steenis
December 1989,
Revue scientifique et technique (International Office of Epizootics),
