BIOMAT Database Logo BIOMAT Database Logo

Ras related oncogene protein as a tumor marker in transitional cell carcinoma of the bladder. 1987

L M Stock, and S A Brosman, and J L Fahey, and B C Liu

An oncogene related protein has been detected in the urine of patients with transitional cell carcinoma (TCC). This is a 55 kilodalton protein (p55) which is immunologically related to the ras oncogene product p21. Sixteen patients with TCC (55%) and none of the controls exhibited high level of p55 expression (greater than or equal to 3X the level of background). There were ten cancer patients (35%) who had 2X the level of background and three patients (10%) who had the level of background. In contrast, there were two non-cancer patients with 2X level of expression (9%) and the remainder (91%) had the background level of p55 expression. The expression of the marker (p55) tends to correlate with tumor grade and stage and is elevated in patients with a history of multiple recurrences. The ras oncogene has been identified in the tissues of a wide variety of cancers and is not a marker which is specific for any single cancer. The identification of its related gene product in the urine may be useful as a marker for TCC.

UI MeSH Term Description Entries
D009856 Oncogene Proteins, Viral Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities. Viral Oncogene Proteins,Viral Transforming Proteins,v-onc Proteins,Transforming Proteins, Viral,v onc Proteins
D011518 Proto-Oncogene Proteins Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity. Cellular Proto-Oncogene Proteins,c-onc Proteins,Proto Oncogene Proteins, Cellular,Proto-Oncogene Products, Cellular,Cellular Proto Oncogene Proteins,Cellular Proto-Oncogene Products,Proto Oncogene Products, Cellular,Proto Oncogene Proteins,Proto-Oncogene Proteins, Cellular,c onc Proteins
D001749 Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER. Bladder Cancer,Bladder Neoplasms,Cancer of Bladder,Bladder Tumors,Cancer of the Bladder,Malignant Tumor of Urinary Bladder,Neoplasms, Bladder,Urinary Bladder Cancer,Bladder Cancers,Bladder Neoplasm,Bladder Tumor,Cancer, Bladder,Cancer, Urinary Bladder,Neoplasm, Bladder,Neoplasm, Urinary Bladder,Tumor, Bladder,Tumors, Bladder,Urinary Bladder Neoplasm
D002295 Carcinoma, Transitional Cell A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS. Carcinomas, Transitional Cell,Cell Carcinoma, Transitional,Cell Carcinomas, Transitional,Transitional Cell Carcinoma,Transitional Cell Carcinomas
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000951 Antigens, Neoplasm Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin. Neoplasm Antigens,Tumor Antigen,Tumor Antigens,Antigen, Tumor,Antigens, Tumor
D019061 src-Family Kinases A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes. Protein-Tyrosine Kinases, src,Src Family Tyrosine Kinase,src Kinase,src Kinases,src Tyrosine Kinase,src-Family Kinase,src-Family Tyrosine Kinase,src Tyrosine Kinases,src-Family Tyrosine Kinases,Kinase, src,Kinase, src Tyrosine,Kinase, src-Family,Kinase, src-Family Tyrosine,Kinases, src,Kinases, src Protein-Tyrosine,Kinases, src Tyrosine,Tyrosine Kinase, src,Tyrosine Kinase, src-Family,Tyrosine Kinases, src,Tyrosine Kinases, src-Family,src Family Kinase,src Family Kinases,src Family Tyrosine Kinases,src Protein-Tyrosine Kinases

Related Publications

L M Stock, and S A Brosman, and J L Fahey, and B C Liu
Transferrin receptor activity as a marker in transitional cell carcinoma of the bladder.
February 1991, British journal of urology,
L M Stock, and S A Brosman, and J L Fahey, and B C Liu
Microvessel density as a prognostic marker for transitional cell carcinoma of the bladder.
April 1998, British journal of urology,
L M Stock, and S A Brosman, and J L Fahey, and B C Liu
Telomerase: a potential marker of bladder transitional cell carcinoma in bladder washes.
March 1998, Clinical cancer research : an official journal of the American Association for Cancer Research,
L M Stock, and S A Brosman, and J L Fahey, and B C Liu
K-RAS mutation in transitional cell carcinoma of urinary bladder.
January 2001, International urology and nephrology,
L M Stock, and S A Brosman, and J L Fahey, and B C Liu
Enhanced expression of Harvey-ras oncogene in FANFT-induced transitional cell carcinoma.
January 1987, Urologia internationalis,
L M Stock, and S A Brosman, and J L Fahey, and B C Liu
Clusterin as a diagnostic and prognostic marker for transitional cell carcinoma of the bladder.
March 2010, Pathology oncology research : POR,
L M Stock, and S A Brosman, and J L Fahey, and B C Liu
Usefulness of urinary nuclear matrix protein 22 (NMP22) as a marker for transitional cell carcinoma of the bladder.
January 2000, Anticancer research,
L M Stock, and S A Brosman, and J L Fahey, and B C Liu
CA-50 as tumour marker in transitional bladder carcinoma.
June 1989, British journal of urology,
L M Stock, and S A Brosman, and J L Fahey, and B C Liu
[Clinical evaluation of nuclear matrix protein 22 as urinary marker of transitional cell carcinoma of bladder].
January 2008, Urologia,
L M Stock, and S A Brosman, and J L Fahey, and B C Liu
c-jun oncogene expression in transitional cell carcinoma of the urinary bladder.
December 1994, British journal of urology,
Copied contents to your clipboard!