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To investigate cell proliferation in regenerating spleen, bone marrow of normal and gamma-irradiated donor mice (3 weeks after 5 Gy) was transfused into lethally irradiated recipients. In the donors and in the recipient spleens numbers of CFU-S and progenitor cells were determined. In the irradiated donors the progenitors were at control level after 3 weeks of recovery although CFU-S were still at 50% of control. Recipients of the irradiated marrow received therefore an increased proportion of progenitors. CFU-C appeared to be self-renewing and/or increased in number due to enhanced CFU-S differentiation, but not the erythroid progenitors. CFU-S self-renewal was reduced after 5 Gy. The data suggest that cell differentiation and maturation proceed during early splenic regeneration. The quantity of CFU-C does not necessarily mirror the situation in the stem cell compartment.
K H von Wangenheim, and
E P Cronkite, and
H P Peterson, and
G E Hübner, and
L E Feinendegen
December 1998,
Scandinavian journal of immunology,
K H von Wangenheim, and
E P Cronkite, and
H P Peterson, and
G E Hübner, and
L E Feinendegen
January 1977,
Acta poloniae pharmaceutica,
K H von Wangenheim, and
E P Cronkite, and
H P Peterson, and
G E Hübner, and
L E Feinendegen
July 1981,
Experimental hematology,
K H von Wangenheim, and
E P Cronkite, and
H P Peterson, and
G E Hübner, and
L E Feinendegen
November 1984,
Cell and tissue kinetics,
K H von Wangenheim, and
E P Cronkite, and
H P Peterson, and
G E Hübner, and
L E Feinendegen
January 1987,
Hematological oncology,
K H von Wangenheim, and
E P Cronkite, and
H P Peterson, and
G E Hübner, and
L E Feinendegen
January 1968,
Strahlentherapie,
K H von Wangenheim, and
E P Cronkite, and
H P Peterson, and
G E Hübner, and
L E Feinendegen
October 1992,
Experimental hematology,
K H von Wangenheim, and
E P Cronkite, and
H P Peterson, and
G E Hübner, and
L E Feinendegen
August 1981,
Blood,
K H von Wangenheim, and
E P Cronkite, and
H P Peterson, and
G E Hübner, and
L E Feinendegen
November 1980,
Blood,
K H von Wangenheim, and
E P Cronkite, and
H P Peterson, and
G E Hübner, and
L E Feinendegen
November 1977,
Blood,
