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The role of prostaglandins (PGs) in the pressor response to norepinephrine (NE) was examined in one-kidney, one clip rabbits with renal artery stenosis for 3-day's duration (3-day clipped rabbits) and in sham operated rabbits with one-kidney without renal artery stenosis. An exaggerated pressor response to NE, 800 ng/kg/min, was observed in the 3-day clipped rabbits, and it was abolished by angiotensin II antagonist, [Sar1, Ile8] angiotensin II (AIIA). Treatment with indomethacin, 10 mg/kg, induced hyperresponsiveness to NE in the sham operated rabbits and also produced a further increase in the response in the 3-day clipped rabbits: the enhanced responses with similar levels were not attenuated by AIIA in both groups. A subdepressor dose of PGE2, 800 ng/kg/min, abolished the hyperresponsiveness in the 3-day clipped rabbits, while subdepressor or depressor dose of PGI2, 10 or 20 ng/kg/min did not, but the concurrent infusion of AIIA with PGI2 attenuated it. These results indicate that PGs, in particular PGE2 might be involved in the enhanced pressor response to NE in the 3-day clipped rabbits in addition to the altered renin-angiotensin system.
M Kogure, and
S Ichikawa, and
S Yagi, and
K Sato, and
H Fujita, and
M Fujie, and
H Kumakura, and
A Yagi, and
T Nakamura, and
K Murata
January 1983,
Hypertension (Dallas, Tex. : 1979),
M Kogure, and
S Ichikawa, and
S Yagi, and
K Sato, and
H Fujita, and
M Fujie, and
H Kumakura, and
A Yagi, and
T Nakamura, and
K Murata
July 1986,
The American journal of physiology,
M Kogure, and
S Ichikawa, and
S Yagi, and
K Sato, and
H Fujita, and
M Fujie, and
H Kumakura, and
A Yagi, and
T Nakamura, and
K Murata
January 1983,
Hypertension (Dallas, Tex. : 1979),
M Kogure, and
S Ichikawa, and
S Yagi, and
K Sato, and
H Fujita, and
M Fujie, and
H Kumakura, and
A Yagi, and
T Nakamura, and
K Murata
November 1985,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M Kogure, and
S Ichikawa, and
S Yagi, and
K Sato, and
H Fujita, and
M Fujie, and
H Kumakura, and
A Yagi, and
T Nakamura, and
K Murata
October 1985,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M Kogure, and
S Ichikawa, and
S Yagi, and
K Sato, and
H Fujita, and
M Fujie, and
H Kumakura, and
A Yagi, and
T Nakamura, and
K Murata
February 1988,
The Tohoku journal of experimental medicine,
M Kogure, and
S Ichikawa, and
S Yagi, and
K Sato, and
H Fujita, and
M Fujie, and
H Kumakura, and
A Yagi, and
T Nakamura, and
K Murata
November 1989,
Journal of cardiovascular pharmacology,
M Kogure, and
S Ichikawa, and
S Yagi, and
K Sato, and
H Fujita, and
M Fujie, and
H Kumakura, and
A Yagi, and
T Nakamura, and
K Murata
September 1970,
Nature,
M Kogure, and
S Ichikawa, and
S Yagi, and
K Sato, and
H Fujita, and
M Fujie, and
H Kumakura, and
A Yagi, and
T Nakamura, and
K Murata
December 1965,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M Kogure, and
S Ichikawa, and
S Yagi, and
K Sato, and
H Fujita, and
M Fujie, and
H Kumakura, and
A Yagi, and
T Nakamura, and
K Murata
November 1987,
Hypertension (Dallas, Tex. : 1979),
