-transparent.png){kind=logo}
The cytotoxicity of hydrogen peroxide in Escherichia coli was investigated after various conditions of drug exposure. Two modes of killing were detected following a 15-min challenge with H2O2 under either aerated or anoxic conditions. Mode one killing occurred at levels below 2.5 mM and mode two killing at concentrations higher than 10 mM. Whereas mode one killing was similar at the two conditions of drug exposure, mode two lethality differed in that aerated cells were more sensitive than anoxic cells. Independently of O2 tension the hydroxyl radical scavenger, thiourea, prevented mode two but not mode one killing by H2O2. Cells treated with the drug at ice temperature did not display mode one killing and mode two lethality occurred only at very high concentrations. We suggest that hydroxyl radicals mediate mode two but not mode one killing by H2O2.
G Brandi, and
P Sestili, and
M A Pedrini, and
L Salvaggio, and
F Cattabeni, and
O Cantoni
September 1985,
Infection and immunity,
G Brandi, and
P Sestili, and
M A Pedrini, and
L Salvaggio, and
F Cattabeni, and
O Cantoni
November 1995,
The Journal of experimental medicine,
G Brandi, and
P Sestili, and
M A Pedrini, and
L Salvaggio, and
F Cattabeni, and
O Cantoni
January 1989,
Free radical research communications,
G Brandi, and
P Sestili, and
M A Pedrini, and
L Salvaggio, and
F Cattabeni, and
O Cantoni
May 1986,
Journal of bacteriology,
G Brandi, and
P Sestili, and
M A Pedrini, and
L Salvaggio, and
F Cattabeni, and
O Cantoni
January 1987,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
G Brandi, and
P Sestili, and
M A Pedrini, and
L Salvaggio, and
F Cattabeni, and
O Cantoni
February 2000,
Mutation research,
G Brandi, and
P Sestili, and
M A Pedrini, and
L Salvaggio, and
F Cattabeni, and
O Cantoni
January 2008,
Indian journal of medical microbiology,
G Brandi, and
P Sestili, and
M A Pedrini, and
L Salvaggio, and
F Cattabeni, and
O Cantoni
July 1987,
Journal of bacteriology,
G Brandi, and
P Sestili, and
M A Pedrini, and
L Salvaggio, and
F Cattabeni, and
O Cantoni
December 2016,
Free radical research,
G Brandi, and
P Sestili, and
M A Pedrini, and
L Salvaggio, and
F Cattabeni, and
O Cantoni
February 2021,
Gene,
