-transparent.png){kind=logo}
As part of a study of potential vaccines against malaria, the protective efficacy of sporozoite subunit vaccines was determined by using the Plasmodium berghei murine malaria model. Mice were immunized with recombinant DNA-produced or synthetic peptide-carrier subunit vaccines derived from the repetitive epitopes of the Plasmodium berghei circumsporozoite gene, or with radiation-attenuated sporozoites. Immunization with subunit vaccines elicited humoral responses that were equivalent to or greater than those elicited by irradiated sporozoites, yet the protection against sporozoite challenge induced by either of the subunit vaccines was far less than that achieved by immunization with attenuated sporozoites. Passive and adoptive transfer studies demonstrated that subunit vaccines elicited predominantly antibody-mediated protection that was easily overcome whereas irradiated sporozoites induced potent cell-mediated immunity that protected against high challenge doses of sporozoites. These studies indicate that new strategies designed to induce cellular immunity will be required for efficacious sporozoite vaccines.
J E Egan, and
J L Weber, and
W R Ballou, and
M R Hollingdale, and
W R Majarian, and
D M Gordon, and
W L Maloy, and
S L Hoffman, and
R A Wirtz, and
I Schneider
January 1989,
Transactions of the Royal Society of Tropical Medicine and Hygiene,
J E Egan, and
J L Weber, and
W R Ballou, and
M R Hollingdale, and
W R Majarian, and
D M Gordon, and
W L Maloy, and
S L Hoffman, and
R A Wirtz, and
I Schneider
January 2017,
Expert review of vaccines,
J E Egan, and
J L Weber, and
W R Ballou, and
M R Hollingdale, and
W R Majarian, and
D M Gordon, and
W L Maloy, and
S L Hoffman, and
R A Wirtz, and
I Schneider
July 1986,
The American journal of tropical medicine and hygiene,
J E Egan, and
J L Weber, and
W R Ballou, and
M R Hollingdale, and
W R Majarian, and
D M Gordon, and
W L Maloy, and
S L Hoffman, and
R A Wirtz, and
I Schneider
April 1987,
Microbial pathogenesis,
J E Egan, and
J L Weber, and
W R Ballou, and
M R Hollingdale, and
W R Majarian, and
D M Gordon, and
W L Maloy, and
S L Hoffman, and
R A Wirtz, and
I Schneider
January 2018,
Frontiers in immunology,
J E Egan, and
J L Weber, and
W R Ballou, and
M R Hollingdale, and
W R Majarian, and
D M Gordon, and
W L Maloy, and
S L Hoffman, and
R A Wirtz, and
I Schneider
September 1990,
Seminars in immunology,
J E Egan, and
J L Weber, and
W R Ballou, and
M R Hollingdale, and
W R Majarian, and
D M Gordon, and
W L Maloy, and
S L Hoffman, and
R A Wirtz, and
I Schneider
January 1989,
Advances in immunology,
J E Egan, and
J L Weber, and
W R Ballou, and
M R Hollingdale, and
W R Majarian, and
D M Gordon, and
W L Maloy, and
S L Hoffman, and
R A Wirtz, and
I Schneider
December 1988,
Biochemical Society transactions,
J E Egan, and
J L Weber, and
W R Ballou, and
M R Hollingdale, and
W R Majarian, and
D M Gordon, and
W L Maloy, and
S L Hoffman, and
R A Wirtz, and
I Schneider
September 1988,
The Southeast Asian journal of tropical medicine and public health,
J E Egan, and
J L Weber, and
W R Ballou, and
M R Hollingdale, and
W R Majarian, and
D M Gordon, and
W L Maloy, and
S L Hoffman, and
R A Wirtz, and
I Schneider
January 1985,
Advances in experimental medicine and biology,
