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Peripheral and central chemosensitivity were assessed in eight abstinent male alcoholic patients and in seven healthy normal male subjects. Hypoxic rebreathing (15% O2, 7% CO2) was used to stimulate the peripheral and central chemoreceptors together. Hyperoxic rebreathing (93% O2, 7% CO2) was used to examine the central chemoreceptor response independently of the peripheral chemoreceptors. Minute ventilation was examined in relation to end-tidal PACO2 under the two conditions. Neither peripheral nor central chemoreceptor responses were significantly altered in the alcoholic as compared to the control subjects. Abnormal chemoreceptor function is therefore unlikely to be an important factor in the development of abnormal respiratory events during sleep in abstinent alcoholic subjects.
D G Lambie, and
E T Tan, and
R H Johnson
January 1984,
Alcohol and alcoholism (Oxford, Oxfordshire),
D G Lambie, and
E T Tan, and
R H Johnson
June 1957,
Ugeskrift for laeger,
D G Lambie, and
E T Tan, and
R H Johnson
January 1981,
Currents in alcoholism,
D G Lambie, and
E T Tan, and
R H Johnson
October 1997,
Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence,
D G Lambie, and
E T Tan, and
R H Johnson
January 1989,
Psychoneuroendocrinology,
D G Lambie, and
E T Tan, and
R H Johnson
June 1987,
Thrombosis research,
D G Lambie, and
E T Tan, and
R H Johnson
May 1994,
The Journal of steroid biochemistry and molecular biology,
D G Lambie, and
E T Tan, and
R H Johnson
January 1988,
Acta psychiatrica Scandinavica,
D G Lambie, and
E T Tan, and
R H Johnson
January 1982,
British medical bulletin,
D G Lambie, and
E T Tan, and
R H Johnson
January 1988,
Haemostasis,
