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Antioxidant activity of cerium dioxide nanoparticles and nanorods in scavenging hydroxyl radicals. 2019

Alexander Filippi, and Fobang Liu, and Jake Wilson, and Steven Lelieveld, and Karsten Korschelt, and Ting Wang, and Yueshe Wang, and Tobias Reich, and Ulrich Pöschl, and Wolfgang Tremel, and Haijie Tong
Multiphase Chemistry Department, Max Planck Institute for Chemistry Mainz 55128 Germany h.tong@mpic.de.

Cerium oxide nanoparticles (CeNPs) have been shown to exhibit antioxidant capabilities, but their efficiency in scavenging reactive oxygen species (ROS) and the underlying mechanisms are not yet well understood. In this study, cerium dioxide nanoparticles (CeNPs) and nanorods (CeNRs) were found to exhibit much stronger scavenging activity than ·OH generation in phosphate buffered saline (PBS) and surrogate lung fluid (SLF). The larger surface area and higher defect density of CeNRs may lead to higher ·OH scavenging activity than for CeNPs. These insights are important to understand the redox activity of cerium nanomaterials and provide clues to the role of CeNPs in biological and environmental processes.

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