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Groups of ten adult male Wistar rats were treated chronically with GnRH agonist for different durations. The responses of pituitary and testis to GnRH agonist were evaluated by serum and testicular testosterone, serum and pituitary LH, and testicular LH receptors. Testicular testosterone and LH receptors were decreased very significantly under our experimental regimen, irrespective of the duration of the treatment Serum testosterone levels were reduced after 10 and 15 injections, but only rats receiving 10 injections showed a significant increase in serum LH levels and decrease of pituitary LH content. The type II gonadotropes of the pars distalis of pituitary were increased in number but showed a higher degree of dilated smooth endoplasmic reticulum with few secretory granules. Many large lipid droplets appeared in the cytoplasms of the Leydig cells. Degenerative changes were observed in most seminiferous tubules following GnRH agonist treatment. Obvious abnormal acrosome and nuclear caps of some spermatids were also observed. The functional changes caused by GnRH agonist coincided with their ultrastructural appearance.
Y B Sun, and
Y W Wu, and
W Liu, and
D Yuan
September 1979,
Life sciences,
Y B Sun, and
Y W Wu, and
W Liu, and
D Yuan
April 1982,
International journal of andrology,
Y B Sun, and
Y W Wu, and
W Liu, and
D Yuan
January 1980,
International journal of fertility,
Y B Sun, and
Y W Wu, and
W Liu, and
D Yuan
November 1979,
Endocrinology,
Y B Sun, and
Y W Wu, and
W Liu, and
D Yuan
January 1985,
Contraception,
Y B Sun, and
Y W Wu, and
W Liu, and
D Yuan
February 1984,
Steroids,
Y B Sun, and
Y W Wu, and
W Liu, and
D Yuan
June 1985,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
Y B Sun, and
Y W Wu, and
W Liu, and
D Yuan
June 1984,
Biology of reproduction,
Y B Sun, and
Y W Wu, and
W Liu, and
D Yuan
December 1978,
Endocrinology,
Y B Sun, and
Y W Wu, and
W Liu, and
D Yuan
February 1983,
Contraception,
