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Waning Immunity Against Respiratory Syncytial Virus During the Coronavirus Disease 2019 Pandemic. 2022
Frederic Reicherz, and
Rui Yang Xu, and
Bahaa Abu-Raya, and
Abdelilah Majdoubi, and
Christina Michalski, and
Liam Golding, and
Aleksandra Stojic, and
Marina Vineta, and
Madison Granoski, and
Zenon Cieslak, and
Anil Chacko, and
Neil Desai, and
Inna Sekirov, and
David J Marchant, and
Pascal M Lavoie
British Columbia Children's Hospital Research Institute, Vancouver, Canada.
Health jurisdictions have seen a near-disappearance of respiratory syncytial virus (RSV) during the first year of the coronavirus disease 2019 (COVID-19) pandemic. Over this corresponding period, we report a reduction in RSV antibody levels and live virus neutralization in sera from women of childbearing age and infants between May to June 2020 and February to June 2021, in British Columbia (BC), Canada. This supports that antibody immunity against RSV is relatively short-lived and that maintaining optimal antibody levels in infants requires repeated maternal viral exposure. Waning immunity may explain the interseasonal resurgence of RSV cases observed in BC and other countries.
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