BIOMAT Database Logo BIOMAT Database Logo

Evaluation of inhalation toxicology after a 90-day xylitol aerosol exposure in Sprague-Dawley rats. 2022

Yushan Tian, and Hongjuan Wang, and Mingxia Wang, and Xianmei Li, and Fengjun Lu, and Shuhao Ma, and Wenming Wang, and Jili Wang, and Jiayou Tang, and Jia Wu, and Pengxia Feng, and Yaning Fu, and Shulei Han, and Tong Liu, and Huan Chen, and Hongwei Hou, and Qingyuan Hu
China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, PR China; Key Laboratory of Tobacco Biological Effects, Zhengzhou 450001, PR China.

Xylitol is a hygroscopic compound known to protect nasal cavity against bacteria. It has also been developed into nasal spray and evaluated as a potential candidate drug for respiratory diseases. Consequently, it is necessary to study its inhalation toxicity. Based on our previous study on its subacute inhalation toxicity, this study aimed to investigate the safety of xylitol inhalation for long-term use. According to the OECD Test Guideline 413, Sprague-Dawley rats were randomly divided into six groups and exposed with different concentrations of xylitol aerosol or air. After exposure for 90-day, the recovery groups were continued to observe for a recovery period of 28-day. No significant changes in body weight were observed between sham and xylitol groups. Several significant differences in hematological, clinical chemistry, bronchoalveolar lavage fluid were observed, which either had no dose-effect relationship for both male and female rats or were restored during the recovery period. Finally, except for high dose group of xylitol, two rats showed a small amount of inflammatory exudate in alveolar and bronchial cavities, which was restored in the recovery period. The rest of rats showed no obvious difference. For the recovery groups, no significant difference was observed between these two groups. In conclusion, the no observable adverse effect level (NOAEL) of xylitol in our subchronic inhalation toxicological experiments was 2.9 mg/L, which indicated that xylitol for rats' long-time inhalation is tolerant and safe.

UI MeSH Term Description Entries
D008297 Male Males
D001992 Bronchoalveolar Lavage Fluid Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung. Alveolar Lavage Fluid,Bronchial Lavage Fluid,Lung Lavage Fluid,Bronchial Alveolar Lavage Fluid,Lavage Fluid, Bronchial,Lavage Fluid, Lung,Pulmonary Lavage Fluid,Alveolar Lavage Fluids,Bronchial Lavage Fluids,Bronchoalveolar Lavage Fluids,Lavage Fluid, Alveolar,Lavage Fluid, Bronchoalveolar,Lavage Fluid, Pulmonary,Lavage Fluids, Alveolar,Lavage Fluids, Bronchial,Lavage Fluids, Bronchoalveolar,Lavage Fluids, Lung,Lavage Fluids, Pulmonary,Lung Lavage Fluids,Pulmonary Lavage Fluids
D005260 Female Females
D000280 Administration, Inhalation The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract. Drug Administration, Inhalation,Drug Administration, Respiratory,Drug Aerosol Therapy,Inhalation Drug Administration,Inhalation of Drugs,Respiratory Drug Administration,Aerosol Drug Therapy,Aerosol Therapy, Drug,Drug Therapy, Aerosol,Inhalation Administration,Administration, Inhalation Drug,Administration, Respiratory Drug,Therapy, Aerosol Drug,Therapy, Drug Aerosol
D000336 Aerosols Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents. Aerosol
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014993 Xylitol A five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D019570 Inhalation Exposure The exposure to potentially harmful chemical, physical, or biological agents by inhaling them. Exposure, Inhalation,Exposures, Inhalation,Inhalation Exposures

Related Publications

Yushan Tian, and Hongjuan Wang, and Mingxia Wang, and Xianmei Li, and Fengjun Lu, and Shuhao Ma, and Wenming Wang, and Jili Wang, and Jiayou Tang, and Jia Wu, and Pengxia Feng, and Yaning Fu, and Shulei Han, and Tong Liu, and Huan Chen, and Hongwei Hou, and Qingyuan Hu
A 90-day toxicology study of high-amylose transgenic rice grain in Sprague-Dawley rats.
December 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Yushan Tian, and Hongjuan Wang, and Mingxia Wang, and Xianmei Li, and Fengjun Lu, and Shuhao Ma, and Wenming Wang, and Jili Wang, and Jiayou Tang, and Jia Wu, and Pengxia Feng, and Yaning Fu, and Shulei Han, and Tong Liu, and Huan Chen, and Hongwei Hou, and Qingyuan Hu
A 90-day toxicology study of transgenic lysine-rich maize grain (Y642) in Sprague-Dawley rats.
February 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Yushan Tian, and Hongjuan Wang, and Mingxia Wang, and Xianmei Li, and Fengjun Lu, and Shuhao Ma, and Wenming Wang, and Jili Wang, and Jiayou Tang, and Jia Wu, and Pengxia Feng, and Yaning Fu, and Shulei Han, and Tong Liu, and Huan Chen, and Hongwei Hou, and Qingyuan Hu
A 90-day toxicological evaluation of Compound 1080 (sodium monofluoroacetate) in Sprague-Dawley rats.
October 2002, Toxicological sciences : an official journal of the Society of Toxicology,
Yushan Tian, and Hongjuan Wang, and Mingxia Wang, and Xianmei Li, and Fengjun Lu, and Shuhao Ma, and Wenming Wang, and Jili Wang, and Jiayou Tang, and Jia Wu, and Pengxia Feng, and Yaning Fu, and Shulei Han, and Tong Liu, and Huan Chen, and Hongwei Hou, and Qingyuan Hu
A 90-day toxicological evaluation of 1,5-anhydro-d-fructose in Sprague-Dawley rats.
January 2005, Drug and chemical toxicology,
Yushan Tian, and Hongjuan Wang, and Mingxia Wang, and Xianmei Li, and Fengjun Lu, and Shuhao Ma, and Wenming Wang, and Jili Wang, and Jiayou Tang, and Jia Wu, and Pengxia Feng, and Yaning Fu, and Shulei Han, and Tong Liu, and Huan Chen, and Hongwei Hou, and Qingyuan Hu
A 90-day toxicology study of meat from genetically modified sheep overexpressing TLR4 in Sprague-Dawley rats.
January 2015, PloS one,
Yushan Tian, and Hongjuan Wang, and Mingxia Wang, and Xianmei Li, and Fengjun Lu, and Shuhao Ma, and Wenming Wang, and Jili Wang, and Jiayou Tang, and Jia Wu, and Pengxia Feng, and Yaning Fu, and Shulei Han, and Tong Liu, and Huan Chen, and Hongwei Hou, and Qingyuan Hu
A 90-day dietary study with fibrillated cellulose in Sprague-Dawley rats.
January 2020, Toxicology reports,
Yushan Tian, and Hongjuan Wang, and Mingxia Wang, and Xianmei Li, and Fengjun Lu, and Shuhao Ma, and Wenming Wang, and Jili Wang, and Jiayou Tang, and Jia Wu, and Pengxia Feng, and Yaning Fu, and Shulei Han, and Tong Liu, and Huan Chen, and Hongwei Hou, and Qingyuan Hu
28-Day inhalation toxicity of graphene nanoplatelets in Sprague-Dawley rats.
September 2016, Nanotoxicology,
Yushan Tian, and Hongjuan Wang, and Mingxia Wang, and Xianmei Li, and Fengjun Lu, and Shuhao Ma, and Wenming Wang, and Jili Wang, and Jiayou Tang, and Jia Wu, and Pengxia Feng, and Yaning Fu, and Shulei Han, and Tong Liu, and Huan Chen, and Hongwei Hou, and Qingyuan Hu
Toxicological evaluation of potassium perfluorobutanesulfonate in a 90-day oral gavage study with Sprague-Dawley rats.
January 2009, Toxicology,
Yushan Tian, and Hongjuan Wang, and Mingxia Wang, and Xianmei Li, and Fengjun Lu, and Shuhao Ma, and Wenming Wang, and Jili Wang, and Jiayou Tang, and Jia Wu, and Pengxia Feng, and Yaning Fu, and Shulei Han, and Tong Liu, and Huan Chen, and Hongwei Hou, and Qingyuan Hu
A 90-day subchronic toxicological assessment of Antrodia cinnamomea in Sprague-Dawley rats.
February 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Yushan Tian, and Hongjuan Wang, and Mingxia Wang, and Xianmei Li, and Fengjun Lu, and Shuhao Ma, and Wenming Wang, and Jili Wang, and Jiayou Tang, and Jia Wu, and Pengxia Feng, and Yaning Fu, and Shulei Han, and Tong Liu, and Huan Chen, and Hongwei Hou, and Qingyuan Hu
A 90-day toxicity study of GmTMT transgenic maize in Sprague-Dawley rats.
April 2017, Regulatory toxicology and pharmacology : RTP,
Copied contents to your clipboard!