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The competence of Xenopus laevis oocytes in various stages of growth to respond to progesterone treatment was investigated. Full-grown (stage 6) oocytes undergo nuclear membrane dissolution and resume meiosis in response to progesterone exposure, while smaller oocytes (stages 3-5; less than 1100 micron in diameter) do not. The defect which prevents 750- to 1050-micron oocytes from responding to progesterone can be overcome by microinjecting cytoplasm withdrawn from a stage 6 oocyte. Germinal vesicle breakdown in these small oocytes occurs on a timetable similar to that of stage 6 oocytes exposed to progesterone and is accompanied by a twofold increase in protein synthesis as well as the activation of MPF. The results argue that a cytoplasmic factor(s) which probably first appears at late stage 5 is required for progesterone responsiveness. The identity and role of the factor(s) in the development of maturation competence and the regulation of maternal mRNA translation are discussed.
M A Taylor, and
L D Smith
June 1976,
Proceedings of the National Academy of Sciences of the United States of America,
M A Taylor, and
L D Smith
April 1975,
Proceedings of the National Academy of Sciences of the United States of America,
M A Taylor, and
L D Smith
May 1978,
Proceedings of the National Academy of Sciences of the United States of America,
M A Taylor, and
L D Smith
April 2013,
Development, growth & differentiation,
M A Taylor, and
L D Smith
October 1974,
Biochemical and biophysical research communications,
M A Taylor, and
L D Smith
July 1972,
Biochemical and biophysical research communications,
M A Taylor, and
L D Smith
September 1979,
Science (New York, N.Y.),
M A Taylor, and
L D Smith
September 1982,
Proceedings of the National Academy of Sciences of the United States of America,
M A Taylor, and
L D Smith
July 1976,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
M A Taylor, and
L D Smith
July 1976,
Nature,
