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The brains of rats with streptozocin-induced diabetes treated with a low-dose insulin regimen (1 IU/day) were studied with morphometric techniques. After 1 yr of diabetes, brain weight decreased slightly (1350 +/- 71 vs. 1521 +/- 55 mg, 2P less than .01) as did the volume of the neocortex (498 +/- 36 vs. 567 +/- 40 mm3, 2P less than .05). A significant loss of neocortical neurons occurred (38 +/- 2 X 10(6) vs. 46 +/- 3 X 10(6), 2P less than .01), and the length of the capillary network in the neocortical tissue shortened disproportionately (405 +/- 102 vs. 631 +/- 47 m, 2P less than .01), leading to increased diffusion distance. The mechanisms underlying cerebral loss in this model are unknown, but abnormalities of the vascular supply with prolongation of the route of diffusion might play a role.
J Jakobsen, and
P Sidenius, and
H J Gundersen, and
R Osterby
November 1989,
Diabetes,
J Jakobsen, and
P Sidenius, and
H J Gundersen, and
R Osterby
January 1994,
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J Jakobsen, and
P Sidenius, and
H J Gundersen, and
R Osterby
August 1996,
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J Jakobsen, and
P Sidenius, and
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R Osterby
September 1992,
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J Jakobsen, and
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R Osterby
January 2000,
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion,
J Jakobsen, and
P Sidenius, and
H J Gundersen, and
R Osterby
November 1991,
Diabetes,
J Jakobsen, and
P Sidenius, and
H J Gundersen, and
R Osterby
July 1984,
Archives of ophthalmology (Chicago, Ill. : 1960),
J Jakobsen, and
P Sidenius, and
H J Gundersen, and
R Osterby
February 1991,
Diabetes,
J Jakobsen, and
P Sidenius, and
H J Gundersen, and
R Osterby
May 1990,
Diabetes,
J Jakobsen, and
P Sidenius, and
H J Gundersen, and
R Osterby
June 1983,
Archives of ophthalmology (Chicago, Ill. : 1960),
