This Issue of Biophysical Reviews (Volume 14, Issue 2) presents a new feature known as an 'Issue Focus' - a contiguous thematic block of five articles placed within a regular Issue format. The current 'Issue Focus' is concerned with the recent developments in Costa Rican biophysical science. The regular aspect of this Issue consists of a 'Meet the Editor' piece by Sabrina Leslie, the first instalment of an ongoing Commentary feature known as the 'Editors' Roundup', and five disparate review articles covering a variety of topics.