-transparent.png){kind=logo}
To elucidate the role of class II major histocompatibility complex antigen expression on pancreatic B cells in the development of diabetes in the non-obese diabetic (NOD) mouse, indirect immunofluorescence was employed for I-A staining on Bouin-fixed pancreas sections of NOD mice (I-A of which was reported as d), B10.GD (I-A, d), BALB/c (I-A, d) and C3H/He (I-A, k). I-A positive islets were observed in all NOD mice examined. Positive reaction was detected in islets both with and without lymphocytic infiltrations. Double staining with anti-insulin, glucagon, somatostatin or pancreatic polypeptide antibodies revealed that I-A positive cells corresponded with insulin cells, while other types of pancreatic islet cells were virtually negative for I-A. Weaker staining was seen in islets of B10.GD and, to a lesser extent, in those of BALB/c mice. C3H/He mouse islet cells showed no I-A expression. These results demonstrated the expression of I-A antigens on pancreatic B cells in the NOD mouse.
T Hanafusa, and
H Fujino-Kurihara, and
A Miyazaki, and
K Yamada, and
H Nakajima, and
J Miyagawa, and
N Kono, and
S Tarui
January 1994,
Autoimmunity,
T Hanafusa, and
H Fujino-Kurihara, and
A Miyazaki, and
K Yamada, and
H Nakajima, and
J Miyagawa, and
N Kono, and
S Tarui
July 1988,
Journal of clinical immunology,
T Hanafusa, and
H Fujino-Kurihara, and
A Miyazaki, and
K Yamada, and
H Nakajima, and
J Miyagawa, and
N Kono, and
S Tarui
January 1988,
Placenta,
T Hanafusa, and
H Fujino-Kurihara, and
A Miyazaki, and
K Yamada, and
H Nakajima, and
J Miyagawa, and
N Kono, and
S Tarui
December 1988,
Journal of the American Academy of Dermatology,
T Hanafusa, and
H Fujino-Kurihara, and
A Miyazaki, and
K Yamada, and
H Nakajima, and
J Miyagawa, and
N Kono, and
S Tarui
February 1998,
Veterinary immunology and immunopathology,
T Hanafusa, and
H Fujino-Kurihara, and
A Miyazaki, and
K Yamada, and
H Nakajima, and
J Miyagawa, and
N Kono, and
S Tarui
January 1988,
Hepatology (Baltimore, Md.),
T Hanafusa, and
H Fujino-Kurihara, and
A Miyazaki, and
K Yamada, and
H Nakajima, and
J Miyagawa, and
N Kono, and
S Tarui
January 1989,
International archives of allergy and applied immunology,
T Hanafusa, and
H Fujino-Kurihara, and
A Miyazaki, and
K Yamada, and
H Nakajima, and
J Miyagawa, and
N Kono, and
S Tarui
November 1985,
Diabetes,
T Hanafusa, and
H Fujino-Kurihara, and
A Miyazaki, and
K Yamada, and
H Nakajima, and
J Miyagawa, and
N Kono, and
S Tarui
November 1983,
Transplantation,
T Hanafusa, and
H Fujino-Kurihara, and
A Miyazaki, and
K Yamada, and
H Nakajima, and
J Miyagawa, and
N Kono, and
S Tarui
April 1986,
Journal of oral pathology,
