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The combination of cyclophosphamide treatment and Toxocara canis infection is known as an effective way of causing a high level of eosinophilia in mice. When this treatment was applied to congenitally anemic, mast cell-deficient W/WV mice, eosinophil response was far less than that of their normal littermate +/+ mice. The degree of the defective eosinophil response in the peripheral blood of W/WV mice was severer than that in the bone marrow. The defective eosinophil response of W/WV mice was completely restored by bone marrow grafting 8 weeks prior to cyclophosphamide treatment and T. canis infection. The kinetics of the recovery of eosinophil response in the bone marrow of W/WV mice after bone marrow grafting was faster than that in the peripheral blood. Chemotactic reactivity of eosinophils obtained from bone marrow or peritoneal cavity of W/WV mice was essentially comparable to that of +/+ mice. These results suggest that, in addition to the production of eosinophils in the bone marrow, mast cell-derived factors play an important role in the mediation of peripheral blood eosinophilia.
Y Nawa, and
M Owhashi, and
J Imai, and
T Abe
January 1986,
International archives of allergy and applied immunology,
Y Nawa, and
M Owhashi, and
J Imai, and
T Abe
October 1986,
Biochimica et biophysica acta,
Y Nawa, and
M Owhashi, and
J Imai, and
T Abe
January 1991,
Bone,
Y Nawa, and
M Owhashi, and
J Imai, and
T Abe
May 1993,
Infection and immunity,
Y Nawa, and
M Owhashi, and
J Imai, and
T Abe
October 1984,
The Journal of parasitology,
Y Nawa, and
M Owhashi, and
J Imai, and
T Abe
September 1985,
Journal of helminthology,
Y Nawa, and
M Owhashi, and
J Imai, and
T Abe
February 1991,
Infection and immunity,
Y Nawa, and
M Owhashi, and
J Imai, and
T Abe
July 1985,
The Journal of investigative dermatology,
Y Nawa, and
M Owhashi, and
J Imai, and
T Abe
August 1982,
Biology of reproduction,
Y Nawa, and
M Owhashi, and
J Imai, and
T Abe
November 1985,
Biology of reproduction,
