Biomaterial Database

Midbrain cholinergic neurons signal negative feedback to promote behavioral flexibility. 2022

Nadine K Gut, and Juan Mena-Segovia

Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA.

Cholinergic neurons of the pedunculopontine nucleus (PPN) are relevant for adaptive behavior. In a recent study, Ruan et al. revealed that PPN cholinergic neurons signal negative feedback during reward omission after contingency changes, which is necessary for switching to new behavioral strategies.

UI	MeSH Term	Description	Entries
D008636	Mesencephalon	The middle of the three primitive cerebral vesicles of the embryonic brain. Without further subdivision, midbrain develops into a short, constricted portion connecting the PONS and the DIENCEPHALON. Midbrain contains two major parts, the dorsal TECTUM MESENCEPHALI and the ventral TEGMENTUM MESENCEPHALI, housing components of auditory, visual, and other sensorimoter systems.	Midbrain,Mesencephalons,Midbrains
D005246	Feedback	A mechanism of communication within a system in that the input signal generates an output response which returns to influence the continued activity or productivity of that system.	Feedbacks
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012201	Reward	An object or a situation that can serve to reinforce a response, to satisfy a motive, or to afford pleasure.	Rewards
D045042	Pedunculopontine Tegmental Nucleus	Dense collection of cells in the caudal pontomesencephalic tegmentum known to play a role in the functional organization of the BASAL GANGLIA and in the modulation of the thalamocortical neuronal system.	Nucleus Tegmentalis Pedunculopontinus,Nucleus, Pedunculopontine Tegmental,Tegmental Nucleus, Pedunculopontine
D059329	Cholinergic Neurons	Neurons whose primary neurotransmitter is ACETYLCHOLINE.	Cholinergic Neuron,Neuron, Cholinergic,Neurons, Cholinergic

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