Association between hair cortisol concentration and behavioral difficulties in children and adolescents. 2022

Cora Charlotte Jahns, and Tanja Poulain, and Mandy Vogel, and Wieland Kiess
LIFE Leipzig Research Center for Civilization Diseases, Leipzig University, Philipp-Rosenthal-Strasse 27, 04103 Leipzig, Germany; Department of Women and Child Health, University Hospital for Children and Adolescents and Center for Pediatric Research, Leipzig University, Liebigstrasse 20a, 04103 Leipzig, Germany. Electronic address: Germanyccjahns@directbox.com.

This study aimed to assess associations between behavioral difficulties and an objectively measurable indicator for long-term stress (hair cortisol) in children and adolescents. We expected increased hair cortisol levels in participants with more externalizing (conduct problems, hyperactivity/inattention) or internalizing (peer relationship problems, emotional problems) behavioral difficulties. Behavioral difficulties were assessed using the parent version of the Strengths and Difficulties Questionnaire (SDQ). Hair cortisol concentration (HCC), measured via liquid chromatography mass spectrometry (LC-MS3), was used as stress marker. A 1 cm strand of hair was cut off from the occipital or parietal cranium closest to the scalp. The study sample comprised 1321 children and adolescents aged between 3 and 17 years participating in the LIFE Child cohort study (Leipzig, Germany). To assess associations, we applied multiple linear regression analyses. Only a few associations met expectations, others contradicted our hypotheses. No association reached statistical significance. The present findings may suggest that behavioral difficulties gathered by SDQ are not associated with stress measured through HCC.

UI MeSH Term Description Entries
D011795 Surveys and Questionnaires Collections of data obtained from voluntary subjects. The information usually takes the form of answers to questions, or suggestions. Community Survey,Nonrespondent,Questionnaire,Questionnaires,Respondent,Survey,Survey Method,Survey Methods,Surveys,Baseline Survey,Community Surveys,Methodology, Survey,Nonrespondents,Questionnaire Design,Randomized Response Technique,Repeated Rounds of Survey,Respondents,Survey Methodology,Baseline Surveys,Design, Questionnaire,Designs, Questionnaire,Methods, Survey,Questionnaire Designs,Questionnaires and Surveys,Randomized Response Techniques,Response Technique, Randomized,Response Techniques, Randomized,Survey, Baseline,Survey, Community,Surveys, Baseline,Surveys, Community,Techniques, Randomized Response
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D005858 Germany A country in central Europe, bordering the Baltic Sea and the North Sea, between the Netherlands and Poland, south of Denmark. The capital is Berlin.
D006197 Hair A filament-like structure consisting of a shaft which projects to the surface of the SKIN from a root which is softer than the shaft and lodges in the cavity of a HAIR FOLLICLE. It is found on most surfaces of the body. Fetal Hair,Hair, Fetal,Lanugo,Fetal Hairs,Hairs,Hairs, Fetal
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006854 Hydrocortisone The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Cortef,Cortisol,Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-,11-Epicortisol,Cortifair,Cortril,Epicortisol,Hydrocortisone, (11 alpha)-Isomer,Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer,11 Epicortisol
D000066553 Problem Behavior Troublesome or disruptive behavioral displays. Behavioral Problem,Disruptive Behavior,Dysfunctional Behavior, Psychology,Behavior, Disruptive,Behavior, Problem,Behavior, Psychology Dysfunctional,Behavioral Problems,Behaviors, Disruptive,Behaviors, Problem,Behaviors, Psychology Dysfunctional,Disruptive Behaviors,Dysfunctional Behaviors, Psychology,Problem Behaviors,Problem, Behavioral,Problems, Behavioral,Psychology Dysfunctional Behavior,Psychology Dysfunctional Behaviors
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D015331 Cohort Studies Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics. Birth Cohort Studies,Birth Cohort Study,Closed Cohort Studies,Cohort Analysis,Concurrent Studies,Historical Cohort Studies,Incidence Studies,Analysis, Cohort,Cohort Studies, Closed,Cohort Studies, Historical,Studies, Closed Cohort,Studies, Concurrent,Studies, Historical Cohort,Analyses, Cohort,Closed Cohort Study,Cohort Analyses,Cohort Studies, Birth,Cohort Study,Cohort Study, Birth,Cohort Study, Closed,Cohort Study, Historical,Concurrent Study,Historical Cohort Study,Incidence Study,Studies, Birth Cohort,Studies, Cohort,Studies, Incidence,Study, Birth Cohort,Study, Closed Cohort,Study, Cohort,Study, Concurrent,Study, Historical Cohort,Study, Incidence

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