Gut modulatory effects of flaxseed derived Maillard reaction products in Sprague-Dawley rats during sub-chronic toxicity. 2022

An-Ran Zheng, and Chao-Kun Wei, and Zhi-Jing Ni, and Kiran Thakur, and Jian-Guo Zhang, and Zhao-Jun Wei
School of Food and Wine, Ningxia University, Yinchuan, 750021, People's Republic of China; School of Biological Science and Engineering, Ningxia Key Laboratory for the Development and Application of Microbial Resources in Extreme Environments, North Minzu University, Yinchuan, 750021, People's Republic of China. Electronic address: zhenganran17@163.com.

Our study aimed to understand the effects of Maillard reaction products (MRPs) intake on intestinal health, in vitro digestion, and fermentation metabolites in Sprague-Dawley (SD) rats. MRPs promoted the digestion of pepsin, but was not conducive to the subsequent in vitro digestion of trypsin. MRPs ingestion increased the propionate in intestine, but it could not change the branched-chain fatty acids (BCFAs) and short-chain fatty acids (SCFAs). However, MRPs ingestion led to an increase in the Lactobacillus abundance in gut. In the high-dose groups, the abundance of genes in partial amino acid and monosaccharide metabolism increased, while in lipid metabolism decreased compared with the middle dose groups. Therefore, the absorption of MRPs was lowered than that of protein and carbohydrates. Through functional predictive analysis, our study could reveal the effects of long-term intake of MRPs on intestinal health in SD rats.

UI MeSH Term Description Entries
D000596 Amino Acids Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins. Amino Acid,Acid, Amino,Acids, Amino
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D015416 Maillard Reaction A group of nonenzymatic reactions in which ALDEHYDES; KETONES; or reducing sugars react with the amino groups of AMINO ACIDS; PEPTIDES; PROTEINS; LIPIDS; or NUCLEIC ACIDS.The reaction with reducing sugars (glycation) results in formation of Schiff bases which undergo Amadori rearrangement and other reactions that result in the irreversible formation of ADVANCED GLYCATION END PRODUCTS (AGEs). Food browning, such as occurs when cooking with high heat (grilling, frying, roasting, etc.) is attributed to the Maillard reaction. Non-enzymatic glycation and subsequent formation of AGEs also occurs in vivo and is accelerated under hyperglycemic and inflammatory conditions, and OXIDATIVE STRESS. Browning Reaction,Food Browning,Fructation,Glucation,Glycation,Lipid Glycation,Non-Enzymatic Glycation,Non-Enzymatic Glycosylation,Nonenzymatic Protein Glycation,Protein Glycation,Ribation,Browning Reactions,Browning, Food,Glycation, Lipid,Glycation, Non-Enzymatic,Glycation, Protein,Glycosylation, Non-Enzymatic,Non Enzymatic Glycation,Non Enzymatic Glycosylation,Protein Glycation, Nonenzymatic,Reaction, Browning,Reaction, Maillard,Reactions, Browning
D017127 Glycation End Products, Advanced A heterogeneous group of compounds derived from rearrangements, oxidation, and cross-linking reactions that follow from non-enzymatic glycation of amino groups in PROTEINS; LIPIDS; or NUCLEIC ACIDS. Their accumulation in vivo accelerates under hyperglycemic, oxidative, or inflammatory conditions. Heat also accelerates the formation of advanced glycation end products (AGEs) such seen with the browning of food during cooking. Advanced Glycation End Product,Advanced Glycation Endproduct,Advanced Maillard Reaction End Product,Glycated Lipids,Glycotoxins,Maillard Product,Maillard Reaction End Product,Maillard Reaction Product,Advanced Glycation End Products,Advanced Glycation Endproducts,Advanced Maillard Reaction End Products,Glycation Endproducts, Advanced,Maillard Products,Maillard Reaction End Products,Maillard Reaction Products,Glycation Endproduct, Advanced,Lipids, Glycated,Product, Maillard Reaction,Products, Maillard,Products, Maillard Reaction,Reaction Products, Maillard
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D019597 Flax A plant genus of the family LINACEAE that is cultivated for its fiber (manufactured into linen cloth). It contains a trypsin inhibitor and the seed is the source of LINSEED OIL. Flaxseed,Linseed,Linum,Linum usitatissimum,Flaxs,Flaxseeds,Linseeds,Linum usitatissimums,Linums,usitatissimums, Linum

Related Publications

An-Ran Zheng, and Chao-Kun Wei, and Zhi-Jing Ni, and Kiran Thakur, and Jian-Guo Zhang, and Zhao-Jun Wei
June 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
An-Ran Zheng, and Chao-Kun Wei, and Zhi-Jing Ni, and Kiran Thakur, and Jian-Guo Zhang, and Zhao-Jun Wei
September 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
An-Ran Zheng, and Chao-Kun Wei, and Zhi-Jing Ni, and Kiran Thakur, and Jian-Guo Zhang, and Zhao-Jun Wei
October 2018, Journal of ethnopharmacology,
An-Ran Zheng, and Chao-Kun Wei, and Zhi-Jing Ni, and Kiran Thakur, and Jian-Guo Zhang, and Zhao-Jun Wei
January 2016, Food & nutrition research,
An-Ran Zheng, and Chao-Kun Wei, and Zhi-Jing Ni, and Kiran Thakur, and Jian-Guo Zhang, and Zhao-Jun Wei
July 2014, Regulatory toxicology and pharmacology : RTP,
An-Ran Zheng, and Chao-Kun Wei, and Zhi-Jing Ni, and Kiran Thakur, and Jian-Guo Zhang, and Zhao-Jun Wei
December 2014, Regulatory toxicology and pharmacology : RTP,
An-Ran Zheng, and Chao-Kun Wei, and Zhi-Jing Ni, and Kiran Thakur, and Jian-Guo Zhang, and Zhao-Jun Wei
May 2012, Journal of ethnopharmacology,
An-Ran Zheng, and Chao-Kun Wei, and Zhi-Jing Ni, and Kiran Thakur, and Jian-Guo Zhang, and Zhao-Jun Wei
January 2014, Biological & pharmaceutical bulletin,
An-Ran Zheng, and Chao-Kun Wei, and Zhi-Jing Ni, and Kiran Thakur, and Jian-Guo Zhang, and Zhao-Jun Wei
March 2021, Food research international (Ottawa, Ont.),
An-Ran Zheng, and Chao-Kun Wei, and Zhi-Jing Ni, and Kiran Thakur, and Jian-Guo Zhang, and Zhao-Jun Wei
January 2021, Inquiry : a journal of medical care organization, provision and financing,
Copied contents to your clipboard!