Polymer encapsulation of anticancer silver-N-heterocyclic carbene complexes. 2018

H A Mohamed, and M Khuphe, and S J Boardman, and S Shepherd, and R M Phillips, and P D Thornton, and C E Willans
School of Chemistry, University of Leeds Woodhouse Lane Leeds LS2 9JT UK c.e.willans@leeds.ac.uk.

Amphiphilic block copolymers have been developed for the encapsulation of organometallic drugs. silver-N-heterocyclic carbene complexes have shown significant promise as anticancer and antibacterial compounds, and have been studied as the payload in these carriers. Simple modification of the N-heterocyclic carbene ligand structure enables solubility properties and interaction with the polymer to be tuned.

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