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Four patients with the acquired immune deficiency syndrome (AIDS) and persistent unexplained hyperkalemia were studied. Testing with cosyntropin (0.25 mg intravenously) revealed normal baseline and stimulated cortisol levels and adequate aldosterone stimulation. The baseline aldosterone level was low for the degree of hyperkalemia. Renin/aldosterone stimulation testing was performed by intravenous injection of 80 mg of furosemide followed by four hours of upright posture. This study showed low baseline renin and aldosterone levels and inadequate renin and aldosterone stimulation. Three patients were subsequently treated with fludrocortisone (0.1 to 0.2 mg per day), with normalization of serum potassium levels. It is concluded that hyporeninemic hypoaldosteronism is responsible for hyperkalemia in some patients with AIDS and that treatment with fludrocortisone is effective in these cases.
M F Kalin, and
L Poretsky, and
D S Seres, and
B Zumoff
February 1989,
Medicina clinica,
M F Kalin, and
L Poretsky, and
D S Seres, and
B Zumoff
February 2002,
The American journal of medicine,
M F Kalin, and
L Poretsky, and
D S Seres, and
B Zumoff
May 1986,
Archives of internal medicine,
M F Kalin, and
L Poretsky, and
D S Seres, and
B Zumoff
January 1982,
Nihon rinsho. Japanese journal of clinical medicine,
M F Kalin, and
L Poretsky, and
D S Seres, and
B Zumoff
June 1984,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
M F Kalin, and
L Poretsky, and
D S Seres, and
B Zumoff
January 1979,
Annual review of medicine,
M F Kalin, and
L Poretsky, and
D S Seres, and
B Zumoff
May 1982,
Harefuah,
M F Kalin, and
L Poretsky, and
D S Seres, and
B Zumoff
April 1986,
The New England journal of medicine,
M F Kalin, and
L Poretsky, and
D S Seres, and
B Zumoff
January 1998,
American journal of nephrology,
M F Kalin, and
L Poretsky, and
D S Seres, and
B Zumoff
January 1997,
Ryoikibetsu shokogun shirizu,
