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Immunoreactive oxytocin (OXT) and arginine8-vasopressin (AVP) levels were measured in limbic areas of the mouse brain (hippocampus, amygdala and basal forebrain). Peptides were measured by radioimmunoassay (RIA). Acute morphine treatment caused a naloxone-reversible increase in OXT content in all three brain regions. The AVP contents of the same brain areas, on the other hand, were not affected by acute morphine treatment. In mice rendered tolerant to/dependent on morphine with subcutaneous morphine pellets, the OXT levels in the limbic brain structures were in the control range (basal forebrain and amygdala) or even decreased (hippocampus). In the latter brain structure of the tolerant animals, the AVP content was also decreased. Naloxone-precipitated withdrawal syndrome in the tolerant/dependent animals resulted in abrupt increases in the OXT and AVP levels of the hippocampus and in the OXT content of the basal forebrain structures.
G L Kovács, and
F Laczi, and
M Vecsernyés, and
K Hódi, and
G Telegdy, and
F A László
January 1979,
Currents in alcoholism,
G L Kovács, and
F Laczi, and
M Vecsernyés, and
K Hódi, and
G Telegdy, and
F A László
November 1988,
Brain research,
G L Kovács, and
F Laczi, and
M Vecsernyés, and
K Hódi, and
G Telegdy, and
F A László
October 1983,
Pharmacology, biochemistry, and behavior,
G L Kovács, and
F Laczi, and
M Vecsernyés, and
K Hódi, and
G Telegdy, and
F A László
July 1963,
Nature,
G L Kovács, and
F Laczi, and
M Vecsernyés, and
K Hódi, and
G Telegdy, and
F A László
June 1974,
British journal of haematology,
G L Kovács, and
F Laczi, and
M Vecsernyés, and
K Hódi, and
G Telegdy, and
F A László
February 1954,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
G L Kovács, and
F Laczi, and
M Vecsernyés, and
K Hódi, and
G Telegdy, and
F A László
December 1967,
The Biochemical journal,
G L Kovács, and
F Laczi, and
M Vecsernyés, and
K Hódi, and
G Telegdy, and
F A László
October 1975,
Journal of medicinal chemistry,
G L Kovács, and
F Laczi, and
M Vecsernyés, and
K Hódi, and
G Telegdy, and
F A László
July 1978,
Life sciences,
G L Kovács, and
F Laczi, and
M Vecsernyés, and
K Hódi, and
G Telegdy, and
F A László
February 1967,
The Journal of laboratory and clinical medicine,
