Incidence, and natural history of inflammatory bowel disease in Castilla y León: Prospective and multicenter epidemiological study. 2023

Rosa María Sáiz-Chumillas, and Jesús Barrio, and Luis Fernández-Salazar, and Lara Arias, and Mónica Sierra Ausín, and Concepción Piñero, and Ana Fuentes Coronel, and Laura Mata, and Mónica Vásquez, and Ana Carbajo, and Noelia Alcaide, and Noelia Cano, and Alejandro Nuñez, and Paola Fradejas, and Mercedes Ibáñez, and Luis Hernández, and Beatriz Sicilia
Hospital Universitario de Burgos, Burgos, España.

BACKGROUND The incidence of inflammatory bowel disease (IBD) is increasing worldwide. OBJECTIVE To evaluate the incidence of IBD in Castilla y León describing clinical characteristics of the patients at diagnosis, the type of treatment received and their clinical course during the first year. METHODS Prospective, multicenter and population-based incidence cohort study. Patients aged >18 years diagnosed during 2017 with IBD (Crohn's disease [CD], ulcerative colitis [UC] and indeterminate colitis [IC]) were included from 8 hospitals in Castilla y León. Epidemiological, clinical, and therapeutic variables were registered. The global incidence and disease incidence were calculated. RESULTS 290 patients were diagnosed with IBD (54.5% UC, 45.2% CD, and 0.3% IC), with a median follow-up of 9 months (range 8-11). The incidence rate of IBD in Castilla y Leon in 2017 was 16.6 cases per 10,000 inhabitants-year (9/105 UC cases and 7.5/105 CD cases), with a UC/CD ratio of 1.2:1. Use of systemic corticosteroids (47% vs 30%; P=.002), immunomodulatory therapy (81% vs 19%; P=.000), biological therapy (29% vs 8%; P=.000), and surgery (11% vs 2%; p=.000) were significatively higher among patients with CD comparing with those with UC. CONCLUSIONS The incidence of patients with UC in our population increases while the incidence of patients with CD remains stable. Patients with CD present a worse natural history of the disease (use of corticosteroids, immunomodulatory therapy, biological therapy and surgery) compared to patients with UC in the first year of follow-up.

UI MeSH Term Description Entries
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D003092 Colitis Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER. Colitides
D003093 Colitis, Ulcerative Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN. Colitis Gravis,Idiopathic Proctocolitis,Inflammatory Bowel Disease, Ulcerative Colitis Type,Ulcerative Colitis
D003424 Crohn Disease A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients. Colitis, Granulomatous,Enteritis, Granulomatous,Enteritis, Regional,Ileitis, Regional,Ileitis, Terminal,Ileocolitis,Crohn's Disease,Crohn's Enteritis,Inflammatory Bowel Disease 1,Regional Enteritis,Crohns Disease,Granulomatous Colitis,Granulomatous Enteritis,Regional Ileitides,Regional Ileitis,Terminal Ileitis
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000305 Adrenal Cortex Hormones HORMONES produced by the ADRENAL CORTEX, including both steroid and peptide hormones. The major hormones produced are HYDROCORTISONE and ALDOSTERONE. Adrenal Cortex Hormone,Corticoid,Corticoids,Corticosteroid,Corticosteroids,Cortex Hormone, Adrenal,Hormone, Adrenal Cortex,Hormones, Adrenal Cortex
D015212 Inflammatory Bowel Diseases Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS. Bowel Diseases, Inflammatory,Inflammatory Bowel Disease
D015331 Cohort Studies Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics. Birth Cohort Studies,Birth Cohort Study,Closed Cohort Studies,Cohort Analysis,Concurrent Studies,Historical Cohort Studies,Incidence Studies,Analysis, Cohort,Cohort Studies, Closed,Cohort Studies, Historical,Studies, Closed Cohort,Studies, Concurrent,Studies, Historical Cohort,Analyses, Cohort,Closed Cohort Study,Cohort Analyses,Cohort Studies, Birth,Cohort Study,Cohort Study, Birth,Cohort Study, Closed,Cohort Study, Historical,Concurrent Study,Historical Cohort Study,Incidence Study,Studies, Birth Cohort,Studies, Cohort,Studies, Incidence,Study, Birth Cohort,Study, Closed Cohort,Study, Cohort,Study, Concurrent,Study, Historical Cohort,Study, Incidence
D015994 Incidence The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases in the population at a given time. Attack Rate,Cumulative Incidence,Incidence Proportion,Incidence Rate,Person-time Rate,Secondary Attack Rate,Attack Rate, Secondary,Attack Rates,Cumulative Incidences,Incidence Proportions,Incidence Rates,Incidence, Cumulative,Incidences,Person time Rate,Person-time Rates,Proportion, Incidence,Rate, Attack,Rate, Incidence,Rate, Person-time,Rate, Secondary Attack,Secondary Attack Rates

Related Publications

Rosa María Sáiz-Chumillas, and Jesús Barrio, and Luis Fernández-Salazar, and Lara Arias, and Mónica Sierra Ausín, and Concepción Piñero, and Ana Fuentes Coronel, and Laura Mata, and Mónica Vásquez, and Ana Carbajo, and Noelia Alcaide, and Noelia Cano, and Alejandro Nuñez, and Paola Fradejas, and Mercedes Ibáñez, and Luis Hernández, and Beatriz Sicilia
June 2015, Medicina clinica,
Rosa María Sáiz-Chumillas, and Jesús Barrio, and Luis Fernández-Salazar, and Lara Arias, and Mónica Sierra Ausín, and Concepción Piñero, and Ana Fuentes Coronel, and Laura Mata, and Mónica Vásquez, and Ana Carbajo, and Noelia Alcaide, and Noelia Cano, and Alejandro Nuñez, and Paola Fradejas, and Mercedes Ibáñez, and Luis Hernández, and Beatriz Sicilia
March 1978, The Journal of bone and joint surgery. American volume,
Rosa María Sáiz-Chumillas, and Jesús Barrio, and Luis Fernández-Salazar, and Lara Arias, and Mónica Sierra Ausín, and Concepción Piñero, and Ana Fuentes Coronel, and Laura Mata, and Mónica Vásquez, and Ana Carbajo, and Noelia Alcaide, and Noelia Cano, and Alejandro Nuñez, and Paola Fradejas, and Mercedes Ibáñez, and Luis Hernández, and Beatriz Sicilia
November 2007, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,
Rosa María Sáiz-Chumillas, and Jesús Barrio, and Luis Fernández-Salazar, and Lara Arias, and Mónica Sierra Ausín, and Concepción Piñero, and Ana Fuentes Coronel, and Laura Mata, and Mónica Vásquez, and Ana Carbajo, and Noelia Alcaide, and Noelia Cano, and Alejandro Nuñez, and Paola Fradejas, and Mercedes Ibáñez, and Luis Hernández, and Beatriz Sicilia
October 2023, Water research,
Rosa María Sáiz-Chumillas, and Jesús Barrio, and Luis Fernández-Salazar, and Lara Arias, and Mónica Sierra Ausín, and Concepción Piñero, and Ana Fuentes Coronel, and Laura Mata, and Mónica Vásquez, and Ana Carbajo, and Noelia Alcaide, and Noelia Cano, and Alejandro Nuñez, and Paola Fradejas, and Mercedes Ibáñez, and Luis Hernández, and Beatriz Sicilia
June 2000, Archivos de bronconeumologia,
Rosa María Sáiz-Chumillas, and Jesús Barrio, and Luis Fernández-Salazar, and Lara Arias, and Mónica Sierra Ausín, and Concepción Piñero, and Ana Fuentes Coronel, and Laura Mata, and Mónica Vásquez, and Ana Carbajo, and Noelia Alcaide, and Noelia Cano, and Alejandro Nuñez, and Paola Fradejas, and Mercedes Ibáñez, and Luis Hernández, and Beatriz Sicilia
June 2009, European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
Rosa María Sáiz-Chumillas, and Jesús Barrio, and Luis Fernández-Salazar, and Lara Arias, and Mónica Sierra Ausín, and Concepción Piñero, and Ana Fuentes Coronel, and Laura Mata, and Mónica Vásquez, and Ana Carbajo, and Noelia Alcaide, and Noelia Cano, and Alejandro Nuñez, and Paola Fradejas, and Mercedes Ibáñez, and Luis Hernández, and Beatriz Sicilia
July 2019, Nutricion hospitalaria,
Rosa María Sáiz-Chumillas, and Jesús Barrio, and Luis Fernández-Salazar, and Lara Arias, and Mónica Sierra Ausín, and Concepción Piñero, and Ana Fuentes Coronel, and Laura Mata, and Mónica Vásquez, and Ana Carbajo, and Noelia Alcaide, and Noelia Cano, and Alejandro Nuñez, and Paola Fradejas, and Mercedes Ibáñez, and Luis Hernández, and Beatriz Sicilia
May 2012, Atencion primaria,
Rosa María Sáiz-Chumillas, and Jesús Barrio, and Luis Fernández-Salazar, and Lara Arias, and Mónica Sierra Ausín, and Concepción Piñero, and Ana Fuentes Coronel, and Laura Mata, and Mónica Vásquez, and Ana Carbajo, and Noelia Alcaide, and Noelia Cano, and Alejandro Nuñez, and Paola Fradejas, and Mercedes Ibáñez, and Luis Hernández, and Beatriz Sicilia
August 2007, Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
Rosa María Sáiz-Chumillas, and Jesús Barrio, and Luis Fernández-Salazar, and Lara Arias, and Mónica Sierra Ausín, and Concepción Piñero, and Ana Fuentes Coronel, and Laura Mata, and Mónica Vásquez, and Ana Carbajo, and Noelia Alcaide, and Noelia Cano, and Alejandro Nuñez, and Paola Fradejas, and Mercedes Ibáñez, and Luis Hernández, and Beatriz Sicilia
October 2010, Anales de pediatria (Barcelona, Spain : 2003),
Copied contents to your clipboard!