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2,3-Dihydrobenzo-dioxine piperidine derivatives as potent and selective α2c antagonists. 2022
Shouming Wang, and
Anssi Haikarainen, and
Antti Pohjakallio, and
Julius Sipilä, and
Janne Kaskinoro, and
Satu Juhila, and
Niina Jalava, and
Mikko Koskinen, and
Marja Vesajoki, and
Esa Kumpulainen, and
Jarmo Pystynen, and
Tuula Koskelainen, and
Patrik Holm, and
David Din Belle
Department of Medicinal Chemistry, Orion Corporation Orion Pharma, Orionintie 1, PL 65, FI-02101, Finland. Electronic address: shouming.wang@orionpharma.com.
In this manuscript, we report a series of benzodioxine methyl piperidine derivatives as highly potent and selective α2C antagonists by ligand design to improve the pharmacokinetics of a previous candidate molecule.
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