BIOMAT Database Logo BIOMAT Database Logo

Vitamin D: sources, physiological role, biokinetics, deficiency, therapeutic use, toxicity, and overview of analytical methods for detection of vitamin D and its metabolites. 2022

Jiří Janoušek, and Veronika Pilařová, and Kateřina Macáková, and Anderson Nomura, and Jéssica Veiga-Matos, and Diana Dias da Silva, and Fernando Remião, and Luciano Saso, and Kateřina Malá-Ládová, and Josef Malý, and Lucie Nováková, and Přemysl Mladěnka
Department of Pharmacognosy, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic.

Vitamin D has a well-known role in the calcium homeostasis associated with the maintenance of healthy bones. It increases the efficiency of the intestinal absorption of dietary calcium, reduces calcium losses in urine, and mobilizes calcium stored in the skeleton. However, vitamin D receptors are present ubiquitously in the human body and indeed, vitamin D has a plethora of non-calcemic functions. In contrast to most vitamins, sufficient vitamin D can be synthesized in human skin. However, its production can be markedly decreased due to factors such as clothing, sunscreens, intentional avoidance of the direct sunlight, or the high latitude of the residence. Indeed, more than one billion people worldwide are vitamin D deficient, and the deficiency is frequently undiagnosed. The chronic deficiency is not only associated with rickets/osteomalacia/osteoporosis but it is also linked to a higher risk of hypertension, type 1 diabetes, multiple sclerosis, or cancer. Supplementation of vitamin D may be hence beneficial, but the intake of vitamin D should be under the supervision of health professionals because overdosing leads to intoxication with severe health consequences. For monitoring vitamin D, several analytical methods are employed, and their advantages and disadvantages are discussed in detail in this review.

UI MeSH Term Description Entries
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D002136 Calcium, Dietary Calcium compounds in DIETARY SUPPLEMENTS or in food that supply the body with calcium. Dietary Calcium
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012279 Rickets Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances. Rachitis,Rachitides
D014807 Vitamin D A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
D014808 Vitamin D Deficiency A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406) Deficiency, Vitamin D,Deficiencies, Vitamin D,Vitamin D Deficiencies
D014815 Vitamins Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body. Vitamin

Related Publications

Jiří Janoušek, and Veronika Pilařová, and Kateřina Macáková, and Anderson Nomura, and Jéssica Veiga-Matos, and Diana Dias da Silva, and Fernando Remião, and Luciano Saso, and Kateřina Malá-Ládová, and Josef Malý, and Lucie Nováková, and Přemysl Mladěnka
Vitamin K - sources, physiological role, kinetics, deficiency, detection, therapeutic use, and toxicity.
March 2022, Nutrition reviews,
Jiří Janoušek, and Veronika Pilařová, and Kateřina Macáková, and Anderson Nomura, and Jéssica Veiga-Matos, and Diana Dias da Silva, and Fernando Remião, and Luciano Saso, and Kateřina Malá-Ládová, and Josef Malý, and Lucie Nováková, and Přemysl Mladěnka
Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination.
February 2021, Nutrients,
Jiří Janoušek, and Veronika Pilařová, and Kateřina Macáková, and Anderson Nomura, and Jéssica Veiga-Matos, and Diana Dias da Silva, and Fernando Remião, and Luciano Saso, and Kateřina Malá-Ládová, and Josef Malý, and Lucie Nováková, and Přemysl Mladěnka
Vitamin A Update: Forms, Sources, Kinetics, Detection, Function, Deficiency, Therapeutic Use and Toxicity.
May 2021, Nutrients,
Jiří Janoušek, and Veronika Pilařová, and Kateřina Macáková, and Anderson Nomura, and Jéssica Veiga-Matos, and Diana Dias da Silva, and Fernando Remião, and Luciano Saso, and Kateřina Malá-Ládová, and Josef Malý, and Lucie Nováková, and Přemysl Mladěnka
Physiological and therapeutic differences between vitamin D, its metabolites and analogues.
December 1977, Clinical endocrinology,
Jiří Janoušek, and Veronika Pilařová, and Kateřina Macáková, and Anderson Nomura, and Jéssica Veiga-Matos, and Diana Dias da Silva, and Fernando Remião, and Luciano Saso, and Kateřina Malá-Ládová, and Josef Malý, and Lucie Nováková, and Přemysl Mladěnka
Overview of extraction methods for analysis of vitamin D and its metabolites in biological samples.
September 2011, Bioanalysis,
Jiří Janoušek, and Veronika Pilařová, and Kateřina Macáková, and Anderson Nomura, and Jéssica Veiga-Matos, and Diana Dias da Silva, and Fernando Remião, and Luciano Saso, and Kateřina Malá-Ládová, and Josef Malý, and Lucie Nováková, and Přemysl Mladěnka
Vitamin D metabolites and analytical challenges.
January 2023, Analytical methods : advancing methods and applications,
Jiří Janoušek, and Veronika Pilařová, and Kateřina Macáková, and Anderson Nomura, and Jéssica Veiga-Matos, and Diana Dias da Silva, and Fernando Remião, and Luciano Saso, and Kateřina Malá-Ládová, and Josef Malý, and Lucie Nováková, and Přemysl Mladěnka
[Vitamin D and its therapeutic use].
January 1985, Annales de medecine interne,
Jiří Janoušek, and Veronika Pilařová, and Kateřina Macáková, and Anderson Nomura, and Jéssica Veiga-Matos, and Diana Dias da Silva, and Fernando Remião, and Luciano Saso, and Kateřina Malá-Ládová, and Josef Malý, and Lucie Nováková, and Přemysl Mladěnka
Vitamin D and its metabolites--supply of patients with various endocrine disorders and comparison of analytical methods.
March 2007, Endocrine regulations,
Jiří Janoušek, and Veronika Pilařová, and Kateřina Macáková, and Anderson Nomura, and Jéssica Veiga-Matos, and Diana Dias da Silva, and Fernando Remião, and Luciano Saso, and Kateřina Malá-Ládová, and Josef Malý, and Lucie Nováková, and Přemysl Mladěnka
[Vitamin D and its metabolites. Therapeutic indications in 1980].
January 1980, Pediatrie,
Jiří Janoušek, and Veronika Pilařová, and Kateřina Macáková, and Anderson Nomura, and Jéssica Veiga-Matos, and Diana Dias da Silva, and Fernando Remião, and Luciano Saso, and Kateřina Malá-Ládová, and Josef Malý, and Lucie Nováková, and Přemysl Mladěnka
[Vitamin D. Physiological and pathological aspects and therapeutic use].
January 1993, Soins. Gynecologie, obstetrique, puericulture, pediatrie,
Copied contents to your clipboard!