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Two new constituents from the aerial parts of Salvia miltiorrhiza Bge. 2023

Fan Yang, and Jia Li, and Xin-Lei Du, and Shi-Jun Wang, and Xiang-Hao Xu, and Yong-Qing Zhang, and Ran Yang
Laboratory of Natural Pharmaceutical Chemistry, Shandong University of Traditional Chinese Medicine, Jinan, China.

Two new constituents: a neolignan, salignan A (1) and a phenolic acid, salside A (2), along with two known compounds (3, 4) have been isolated from the aerial parts of Salvia miltiorrhiza Bge. All structures were assigned on the basis of detailed spectroscopic analyses. The absolute configuration of 1 was characterised by electronic circular dichroism (ECD) spectroscopy. Compounds 1 and 3 exhibited moderate inhibitory effects on nitric oxide (NO) production in LPS-induced RAW264.7 cells, and the IC50 values are 11.58 and 10.73 μM, respectively. Compound 4 displayed moderate antioxidant activity to scavenge DPPH and ABTS radicals, and the IC50 values are 7.96 and 1.10 μM, respectively.

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