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The short-term effect of chenodeoxycholic acid administration on the excretion of protoporphyrin was investigated in 5 patients suffering from erythrohepatic protoporphyria. Faeces were collected for 7 days, 10 ml of bile was sampled daily and blood was drawn every 2 to 3 days. Chenodeoxycholic acid was given in a dosage of 15 mg/kg/day from the 8th day. Collection of faeces, bile and blood was then continued for 10 more days. Protoporphyrin concentration was measured by high-pressure liquid chromatography and fluorometry. Following the administration of chenodeoxycholic acid the concentration of protoporphyrin in faeces and bile decreased significantly. In addition, all patients showed a significant decrease in erythrocyte protoporphyrin concentration. These results indicate that chenodeoxycholic acid therapy causes a marked decrease in the excretion of protoporphyrin in patients with erythrohepatic protoporphyria. The subsequent decrease in erythrocyte protoporphyrin suggests that chenodeoxycholic acid inhibits the production of protoporphyrin in the liver.
J Van Hattum, and
H Baart de la Faille, and
J W Van den Berg, and
A Edixhoven-Bosdijk, and
J H Wilson
January 1988,
Dermatologische Monatschrift,
J Van Hattum, and
H Baart de la Faille, and
J W Van den Berg, and
A Edixhoven-Bosdijk, and
J H Wilson
June 1972,
California medicine,
J Van Hattum, and
H Baart de la Faille, and
J W Van den Berg, and
A Edixhoven-Bosdijk, and
J H Wilson
July 1985,
Der Internist,
J Van Hattum, and
H Baart de la Faille, and
J W Van den Berg, and
A Edixhoven-Bosdijk, and
J H Wilson
January 1986,
Patologia polska,
J Van Hattum, and
H Baart de la Faille, and
J W Van den Berg, and
A Edixhoven-Bosdijk, and
J H Wilson
October 1983,
Deutsche medizinische Wochenschrift (1946),
J Van Hattum, and
H Baart de la Faille, and
J W Van den Berg, and
A Edixhoven-Bosdijk, and
J H Wilson
July 1985,
Der Internist,
J Van Hattum, and
H Baart de la Faille, and
J W Van den Berg, and
A Edixhoven-Bosdijk, and
J H Wilson
July 1992,
Deutsche medizinische Wochenschrift (1946),
J Van Hattum, and
H Baart de la Faille, and
J W Van den Berg, and
A Edixhoven-Bosdijk, and
J H Wilson
August 1978,
Annals of clinical research,
J Van Hattum, and
H Baart de la Faille, and
J W Van den Berg, and
A Edixhoven-Bosdijk, and
J H Wilson
November 1989,
Deutsche medizinische Wochenschrift (1946),
J Van Hattum, and
H Baart de la Faille, and
J W Van den Berg, and
A Edixhoven-Bosdijk, and
J H Wilson
January 1974,
Acta dermato-venereologica,
