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Eighteen patients with metastatic mixed mesodermal sarcoma of the uterus received cisplatin therapy at the University of Texas (UT) M.D. Anderson Hospital and Tumor Institute at Houston. The dose of cisplatin varied from 75 mg/m2 to 100 mg/m2. Previous therapy included surgery in 11 patients, radiotherapy in two patients, and surgery plus radiotherapy in four patients. One patient had no prior therapy. Seven patients had also received prior chemotherapy with doxorubicin. Of 12 patients with measurable disease, one (8%) had a complete response and four (33%) had a partial response for an overall response rate of 42%. The median progression-free survival of patients treated with cisplatin as first- and second-line therapy was 4.5 and 5.5 months, respectively. Cisplatin demonstrated moderate activity with mild toxicity in this group of patients with metastatic mixed mesodermal uterine sarcomas. Further studies including cisplatin-containing combination regimens seem to be warranted.
D M Gershenson, and
J J Kavanagh, and
L J Copeland, and
C L Edwards, and
C A Stringer, and
J T Wharton
March 1973,
The American journal of roentgenology, radium therapy, and nuclear medicine,
D M Gershenson, and
J J Kavanagh, and
L J Copeland, and
C L Edwards, and
C A Stringer, and
J T Wharton
November 1984,
Cancer treatment reports,
D M Gershenson, and
J J Kavanagh, and
L J Copeland, and
C L Edwards, and
C A Stringer, and
J T Wharton
April 1952,
New York state journal of medicine,
D M Gershenson, and
J J Kavanagh, and
L J Copeland, and
C L Edwards, and
C A Stringer, and
J T Wharton
November 1954,
Obstetrics and gynecology,
D M Gershenson, and
J J Kavanagh, and
L J Copeland, and
C L Edwards, and
C A Stringer, and
J T Wharton
October 1959,
Geneeskundige gids,
D M Gershenson, and
J J Kavanagh, and
L J Copeland, and
C L Edwards, and
C A Stringer, and
J T Wharton
March 1956,
Belgisch tijdschrift voor geneeskunde,
D M Gershenson, and
J J Kavanagh, and
L J Copeland, and
C L Edwards, and
C A Stringer, and
J T Wharton
October 1953,
American journal of obstetrics and gynecology,
D M Gershenson, and
J J Kavanagh, and
L J Copeland, and
C L Edwards, and
C A Stringer, and
J T Wharton
January 1989,
Patologia polska,
D M Gershenson, and
J J Kavanagh, and
L J Copeland, and
C L Edwards, and
C A Stringer, and
J T Wharton
January 1956,
Acta - Unio Internationalis Contra Cancrum,
D M Gershenson, and
J J Kavanagh, and
L J Copeland, and
C L Edwards, and
C A Stringer, and
J T Wharton
September 1972,
Zentralblatt fur Gynakologie,
