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The in vitro clonogenic assay has been used to assess the biological effects of estradiol-17 beta (E 2) and an antiestrogen, tamoxifen (TAM) on human breast cancer, and the results were compared with the estrogen receptor status (ER). The sera used were treated with dextran-coated charcoal to avoid the modification effects of the endogenous hormones. There was a significant difference between ER (+) and ER (-) breast cancers in the incidence of cases in which the plating efficiency of cancers increased more than 50% over those of untreated control by adding 10(-8) M of E 2 (40.2% vs. 21.3%). TAM, 10(-6) M revealed a less than 50% colony formation of the control in 30.5% of ER (+) cancers, whereas only 13.0% of ER (-) cancers showed a response to TAM.
Y Nomura, and
H Tashiro, and
F Takaekoh, and
K Hisamatsu
August 1985,
Gan to kagaku ryoho. Cancer & chemotherapy,
Y Nomura, and
H Tashiro, and
F Takaekoh, and
K Hisamatsu
January 1985,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
Y Nomura, and
H Tashiro, and
F Takaekoh, and
K Hisamatsu
January 1983,
Neoplasma,
Y Nomura, and
H Tashiro, and
F Takaekoh, and
K Hisamatsu
April 1985,
Journal of the National Cancer Institute,
Y Nomura, and
H Tashiro, and
F Takaekoh, and
K Hisamatsu
January 1984,
Cancer chemotherapy and pharmacology,
Y Nomura, and
H Tashiro, and
F Takaekoh, and
K Hisamatsu
January 1977,
Progress in clinical and biological research,
Y Nomura, and
H Tashiro, and
F Takaekoh, and
K Hisamatsu
January 1976,
Journal of steroid biochemistry,
Y Nomura, and
H Tashiro, and
F Takaekoh, and
K Hisamatsu
September 1985,
L'union medicale du Canada,
Y Nomura, and
H Tashiro, and
F Takaekoh, and
K Hisamatsu
January 1976,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
Y Nomura, and
H Tashiro, and
F Takaekoh, and
K Hisamatsu
May 1981,
Cancer,
