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Doravirine Concentrations and Human Immunodeficiency Virus Type 1 RNA in the Genital Fluids of Virologically Suppressed Adults Switching to Doravirine Plus Emtricitabine/Tenofovir Alafenamide. 2022
Sofía Scévola, and
Arkaitz Imaz, and
Mackenzie L Cottrell, and
Jordi Niubo, and
Brian Van Horne, and
Juan Tiraboschi, and
Maria Saumoy, and
Sandra Morenilla, and
Irene Soriano, and
Angela D M Kashuba, and
Daniel Podzamczer
HIV and STI Unit, Department of Infectious Diseases, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
Doravirine (DOR) concentrations and HIV-1 RNA were evaluated in genital fluids from adults with HIV on stable therapy who switched to DOR + FTC/TAF. High protein-unbound DOR concentrations were observed in both seminal plasma and cervicovaginal fluid. DOR + FTC/TAF maintained viral suppression in genital fluids in all but 1 participant.
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