Biomaterial Database

Brain-Derived Neurotropic Factor in Neurodegenerative Disorders. 2022

Abdallah Mohammad Ibrahim, and Lalita Chauhan, and Aditi Bhardwaj, and Anjali Sharma, and Faizana Fayaz, and Bhumika Kumar, and Mohamed Alhashmi, and Noora AlHajri, and Md Sabir Alam, and Faheem Hyder Pottoo

Department of Fundamentals of Nursing, College of Nursing, Imam Abdul Rahman Bin Faisal University, Dammam 31441, Saudi Arabia.

Globally, neurodegenerative diseases cause a significant degree of disability and distress. Brain-derived neurotrophic factor (BDNF), primarily found in the brain, has a substantial role in the development and maintenance of various nerve roles and is associated with the family of neurotrophins, including neuronal growth factor (NGF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5). BDNF has affinity with tropomyosin receptor kinase B (TrKB), which is found in the brain in large amounts and is expressed in several cells. Several studies have shown that decrease in BDNF causes an imbalance in neuronal functioning and survival. Moreover, BDNF has several important roles, such as improving synaptic plasticity and contributing to long-lasting memory formation. BDNF has been linked to the pathology of the most common neurodegenerative disorders, such as Alzheimer's and Parkinson's disease. This review aims to describe recent efforts to understand the connection between the level of BDNF and neurodegenerative diseases. Several studies have shown that a high level of BDNF is associated with a lower risk for developing a neurodegenerative disease.