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Synthesis, Redox and Spectroscopic Properties of Pterin of Molybdenum Cofactors. 2022

Kyle J Colston, and Partha Basu
Department of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA.

Pterins are bicyclic heterocycles that are found widely across Nature and are involved in a variety of biological functions. Notably, pterins are found at the core of molybdenum cofactor (Moco) containing enzymes in the molybdopterin (MPT) ligand that coordinates molybdenum and facilitates cofactor activity. Pterins are diverse and can be widely functionalized to tune their properties. Herein, the general methods of synthesis, redox and spectroscopic properties of pterin are discussed to provide more insight into pterin chemistry and their importance to biological systems.

UI MeSH Term Description Entries
D008982 Molybdenum A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase. Molybdenum-98,Molybdenum 98
D010084 Oxidation-Reduction A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471). Redox,Oxidation Reduction
D011622 Pterins Compounds based on 2-amino-4-hydroxypteridine. Pterin
D000090006 Molybdenum Cofactors Enzyme co-factors that contain MOLYBDENUM. They play an essential role in a variety of cellular REDOX reactions. Molybdenum-Containing Cofactors,Pterin-based Molybdenum Cofactor,Pterin-based Molybdenum Cofactors,Cofactor, Pterin-based Molybdenum,Cofactors, Molybdenum,Cofactors, Molybdenum-Containing,Cofactors, Pterin-based Molybdenum,Molybdenum Cofactor, Pterin-based,Molybdenum Cofactors, Pterin-based,Molybdenum Containing Cofactors,Pterin based Molybdenum Cofactor,Pterin based Molybdenum Cofactors
D013057 Spectrum Analysis The measurement of the amplitude of the components of a complex waveform throughout the frequency range of the waveform. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Spectroscopy,Analysis, Spectrum,Spectrometry

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