A self-pressure-driven blood plasma-separation device for point-of-care diagnostics. 2022

Hanbi Kim, and Hyeonseek Park, and Doo Ryeon Chung, and Taekyung Kim, and Eunkyoung Park, and Minhee Kang
Biomedical Engineering Research Center, Smart Healthcare Research Institute, Samsung Medical Center, Seoul, South Korea; Department of Medical Device Management and Research, SAIHST (Samsung Advanced Institute for Health Sciences & Technology), Sungkyunkwan University, Seoul, South Korea.

We aimed to develop a portable, simple-to-use, and self-pressure-driven blood plasma-separation device that can be combined with rapid diagnostic test kits. This simple, disposable, and electrical equipment-free apparatus has been designed to separate plasma from a few microliters of blood with only hand-powered operation. The refined plasma sample is then delivered to multiple lateral flow assay kits directly connected to the device for the detection of various serological markers. The required time for all steps was just 1 min. We validated the device through multifaceted experiments. The developed multifunctional device enables to perform all blood test steps of diagnostic medical examination at the point-of-care.

UI MeSH Term Description Entries
D010949 Plasma The residual portion of BLOOD that is left after removal of BLOOD CELLS by CENTRIFUGATION without prior BLOOD COAGULATION. Blood Plasma,Fresh Frozen Plasma,Blood Plasmas,Fresh Frozen Plasmas,Frozen Plasma, Fresh,Frozen Plasmas, Fresh,Plasma, Blood,Plasma, Fresh Frozen,Plasmas,Plasmas, Blood,Plasmas, Fresh Frozen
D011933 Reagent Kits, Diagnostic Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use. Diagnostic Reagent Kits,Diagnostic Reagents and Test Kits,Diagnostic Test Kits,In Vitro Diagnostic Device,In Vitro Diagnostic Devices,In Vitro Diagnostic Medical Device,In Vitro Diagnostic Medical Devices,Kits, Diagnostic Reagent,Diagnostic Reagent Kit,Diagnostic Test Kit,Kit, Diagnostic Reagent,Kit, Diagnostic Test,Kits, Diagnostic Test,Reagent Kit, Diagnostic,Test Kit, Diagnostic,Test Kits, Diagnostic
D000067716 Point-of-Care Testing Allows patient diagnoses in the physician’s office, in other ambulatory setting or at bedside. The results of care are timely, and allow rapid treatment to the patient. (from NIH Fact Sheet Point-of-Care Diagnostic Testing, 2010.) Bedside Testing,Point-Of-Care Diagnostic Testing,Point-Of-Care Diagnostic Tests,Point-Of-Care Diagnostics,Point-Of-Care Test,Point-Of-Care Tests,Point of Care Testing,Diagnostic Test, Point-Of-Care,Diagnostic Testing, Point-Of-Care,Diagnostic Tests, Point-Of-Care,Diagnostic, Point-Of-Care,Diagnostics, Point-Of-Care,Point Of Care Diagnostic Testing,Point Of Care Diagnostic Tests,Point Of Care Diagnostics,Point Of Care Test,Point Of Care Tests,Point-Of-Care Diagnostic,Point-Of-Care Diagnostic Test,Test, Point-Of-Care,Test, Point-Of-Care Diagnostic,Testing, Bedside,Testing, Point-Of-Care Diagnostic,Testing, Point-of-Care,Tests, Point-Of-Care,Tests, Point-Of-Care Diagnostic
D019095 Point-of-Care Systems Laboratory and other services provided to patients at the bedside. These include diagnostic and laboratory testing using automated information entry. Bedside Computing,Point of Care Technology,Bedside Technology,Point-of-Care,Bedside Technologies,Computing, Bedside,Point of Care,Point of Care Systems,Point-of-Care System,Systems, Point-of-Care,Technologies, Bedside,Technology, Bedside

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