BIOMAT Database Logo BIOMAT Database Logo

Combination of Houttuynia cordata polysaccharide and Lactiplantibacillus plantarum P101 alleviates acute liver injury by regulating gut microbiota in mice. 2022

Xiaowei Xu, and Shanji Liu, and Yu Zhao, and Mengqi Wang, and Liehai Hu, and Wenjuan Li, and Hengyi Xu
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, China.

BACKGROUND Polysaccharides and probiotics can play an outstanding role in the treatment of liver disease by regulating gut microbiota. Recently, the combined therapeutic effect of probiotics and polysaccharides has attracted the attention of researchers. Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent carbon tetrachloride (CCl4 )-induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored. RESULTS Results showed that, in mice, HCP combined with L. plantarum P101 significantly alleviated oxidative stress and inflammatory injury in the liver by activating Nrf2 signals and inhibiting NF-κB signals. The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundance of beneficial bacteria such as Alloprevotella, Roseburia, and Akkermansia, but reduced that of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus, and Escherichia-Shigella. Correlation analysis also indicated that the expression of Nrf2 and TLR4/NF-κB was connected to the changes in gut microbiota composition. Houttuynia cordata polysaccharide combined with L. plantarum P101 can regulate the gut microbiota and then mediate the gut-liver axis to activate the antioxidant pathway and inhibit inflammatory responses, thereby alleviating CCl4 -induced ALI. CONCLUSIONS Our study provided a new perspective on the use of polysaccharides combined with probiotics in the treatment of liver disease. © 2022 Society of Chemical Industry.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D011134 Polysaccharides Long chain polymeric CARBOHYDRATES composed of MONOSACCHARIDES linked by glycosidic bonds. Glycan,Glycans,Polysaccharide
D000069196 Gastrointestinal Microbiome All of the microbial organisms that naturally exist within the GASTROINTESTINAL TRACT. Enteric Bacteria,Gastric Microbiome,Gastrointestinal Flora,Gastrointestinal Microbial Community,Gastrointestinal Microbiota,Gastrointestinal Microflora,Gut Flora,Gut Microbiome,Gut Microbiota,Gut Microflora,Intestinal Flora,Intestinal Microbiome,Intestinal Microbiota,Intestinal Microflora,Bacteria, Enteric,Flora, Gastrointestinal,Flora, Gut,Flora, Intestinal,Gastric Microbiomes,Gastrointestinal Microbial Communities,Gastrointestinal Microbiomes,Gastrointestinal Microbiotas,Gut Microbiomes,Gut Microbiotas,Intestinal Microbiomes,Intestinal Microbiotas,Microbial Community, Gastrointestinal,Microbiome, Gastric,Microbiome, Gastrointestinal,Microbiome, Gut,Microbiome, Intestinal,Microbiota, Gastrointestinal,Microbiota, Gut,Microbiota, Intestinal,Microflora, Gastrointestinal,Microflora, Gut,Microflora, Intestinal
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D016328 NF-kappa B Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA. Immunoglobulin Enhancer-Binding Protein,NF-kappa B Complex,Nuclear Factor kappa B,Transcription Factor NF-kB,kappa B Enhancer Binding Protein,Ig-EBP-1,NF-kB,NF-kappaB,Nuclear Factor-Kappab,Complex, NF-kappa B,Enhancer-Binding Protein, Immunoglobulin,Factor NF-kB, Transcription,Factor-Kappab, Nuclear,Ig EBP 1,Immunoglobulin Enhancer Binding Protein,NF kB,NF kappa B Complex,NF kappaB,NF-kB, Transcription Factor,Nuclear Factor Kappab,Transcription Factor NF kB
D041963 Bacteroidetes A phylum of bacteria comprising four classes; Bacteroidia, Cytophagia, Flavobacteriia, and Sphingobacteriia. CFB Group Bacteria,Cytophaga-Flavobacteria-Bacteroides Group Bacteria,Cytophagales
D048191 Lactobacillus plantarum A species of rod-shaped, LACTIC ACID bacteria used in PROBIOTICS and SILAGE production.
D051267 NF-E2-Related Factor 2 A basic-leucine zipper transcription factor that was originally described as a transcriptional regulator controlling expression of the BETA-GLOBIN gene. It may regulate the expression of a wide variety of genes that play a role in protecting cells from oxidative damage. Nfe2l2 Protein,Nuclear Factor (Erythroid-Derived 2)-Like 2 Protein,Nuclear Factor E2-Related Factor 2,NF E2 Related Factor 2,Nuclear Factor E2 Related Factor 2
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D052859 Houttuynia A plant genus of the family SAURURACEAE. Members contain aristolactams. Dokudami,Houttuynia cordata,Dokudamus

Related Publications

Xiaowei Xu, and Shanji Liu, and Yu Zhao, and Mengqi Wang, and Liehai Hu, and Wenjuan Li, and Hengyi Xu
Lactiplantibacillus plantarum ELF051 Alleviates Antibiotic-Associated Diarrhea by Regulating Intestinal Inflammation and Gut Microbiota.
August 2023, Probiotics and antimicrobial proteins,
Xiaowei Xu, and Shanji Liu, and Yu Zhao, and Mengqi Wang, and Liehai Hu, and Wenjuan Li, and Hengyi Xu
Indole-3-acetamide from gut microbiota activated hepatic AhR and mediated the remission effect of Lactiplantibacillus plantarum P101 on alcoholic liver injury in mice.
November 2023, Food & function,
Xiaowei Xu, and Shanji Liu, and Yu Zhao, and Mengqi Wang, and Liehai Hu, and Wenjuan Li, and Hengyi Xu
Lactiplantibacillus plantarum AR113 Exhibit Accelerated Liver Regeneration by Regulating Gut Microbiota and Plasma Glycerophospholipid.
January 2021, Frontiers in microbiology,
Xiaowei Xu, and Shanji Liu, and Yu Zhao, and Mengqi Wang, and Liehai Hu, and Wenjuan Li, and Hengyi Xu
Houttuynia cordata polysaccharide alleviated intestinal injury and modulated intestinal microbiota in H1N1 virus infected mice.
March 2019, Chinese journal of natural medicines,
Xiaowei Xu, and Shanji Liu, and Yu Zhao, and Mengqi Wang, and Liehai Hu, and Wenjuan Li, and Hengyi Xu
Lactiplantibacillus plantarum CCFM8661 alleviates D-galactose-induced brain aging in mice by the regulation of the gut microbiota.
November 2023, Food & function,
Xiaowei Xu, and Shanji Liu, and Yu Zhao, and Mengqi Wang, and Liehai Hu, and Wenjuan Li, and Hengyi Xu
Lactiplantibacillus plantarum Reduced Renal Calcium Oxalate Stones by Regulating Arginine Metabolism in Gut Microbiota.
January 2021, Frontiers in microbiology,
Xiaowei Xu, and Shanji Liu, and Yu Zhao, and Mengqi Wang, and Liehai Hu, and Wenjuan Li, and Hengyi Xu
Antitumor effect of exopolysaccharide from Lactiplantibacillus plantarum WLPL09 on melanoma mice via regulating immunity and gut microbiota.
January 2024, International journal of biological macromolecules,
Xiaowei Xu, and Shanji Liu, and Yu Zhao, and Mengqi Wang, and Liehai Hu, and Wenjuan Li, and Hengyi Xu
Lactiplantibacillus plantarum and faecal microbiota transplantation can improve colitis in mice by affecting gut microbiota and metabolomics.
December 2023, Beneficial microbes,
Xiaowei Xu, and Shanji Liu, and Yu Zhao, and Mengqi Wang, and Liehai Hu, and Wenjuan Li, and Hengyi Xu
Bacillus subtilis pretreatment alleviates ethanol-induced acute liver injury by regulating the Gut-liver axis in mice.
April 2023, Toxicology,
Xiaowei Xu, and Shanji Liu, and Yu Zhao, and Mengqi Wang, and Liehai Hu, and Wenjuan Li, and Hengyi Xu
Rhubarb Alleviates Acute Lung Injury by Modulating Gut Microbiota Dysbiosis in Mice.
February 2022, Current microbiology,
Copied contents to your clipboard!