The authors share their experience in the clinical observation and treatment of 72 children with acute intoxications by tricyclic antidepressants. The syndromes, forming the clinical picture of the acute intoxication at that age were the cerebrotoxic, cholinolytic and cardiotoxic ones. According to their content, the intoxication advanced in three forms: light, moderately severe and severe. The complex application of the therapeutic methods from the unified therapeutic system for the treatment of acute intoxications gave lethality of 5.5%, determined, primarily, by the late admittance of the children for hospital treatment in a state of decompensated phase of exotoxic shock. The anamnestic data for administration of tricyclic preparation in toxic and lethal doses is a signal for hospitalization of the chill with the inclusion of all necessary procedures with a dynamic follow up of its state.