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The immunohistological study of the large intestines excised from 20 patients with ulcerous colitis and Crohn's disease was made with the use of the indirect immunofluorescence test. A considerable increase in the number of IgG immunocytes has been noted in the lamina propria of the mucous membrane, especially in infiltrations around ulcers. In cases of a highly active inflammatory process accompanied by the pronounced destruction of the epithelium, IgG and C3, C4, C9 were detected in the epithelium of crypts and in blood vessels of the mucous membrane and the submucosa. One-third of the patients showed a decrease in the number of crypts with secretory and serum IgA. The authors suggest that immune complexes take part in maintaining the chronic inflammatory process.
E A Konovich, and
B V Kirkin, and
I L Khalif
January 1975,
Digestion,
E A Konovich, and
B V Kirkin, and
I L Khalif
April 1974,
Wiener klinische Wochenschrift,
E A Konovich, and
B V Kirkin, and
I L Khalif
March 1979,
Dermatologische Monatschrift,
E A Konovich, and
B V Kirkin, and
I L Khalif
January 1980,
Revista espanola de estomatologia,
E A Konovich, and
B V Kirkin, and
I L Khalif
March 1986,
Scandinavian journal of gastroenterology,
E A Konovich, and
B V Kirkin, and
I L Khalif
June 1984,
Journal of clinical & laboratory immunology,
E A Konovich, and
B V Kirkin, and
I L Khalif
February 1985,
Klinicheskaia khirurgiia,
E A Konovich, and
B V Kirkin, and
I L Khalif
January 1972,
International archives of allergy and applied immunology,
E A Konovich, and
B V Kirkin, and
I L Khalif
June 1988,
Klinicheskaia meditsina,
E A Konovich, and
B V Kirkin, and
I L Khalif
January 1993,
Clinical and experimental obstetrics & gynecology,
