Changes in phrenic nerve compound muscle action potential in streptozotocin-induced diabetic rats. 2022

Marcelo C Ferrari, and João V Peixoto, and Rosalvo H Fogaça, and Fernando A Dias
Laboratory of Cardiovascular Physiology and Pathophysiology, Department of Physiology, Federal University of Paraná, Brazil.

To evaluate the phrenic nerve compound muscle action potential (CMAP) in rats after diabetes mellitus (DM) induction. Twenty DM animals (intravenous streptozotocin, 45 mg.kg-1) and 25 controls underwent CMAP analysis before and 30, 60 and 90 days after DM induction. Amplitude (mV) progressively declined in DM group after 30 (Mean difference (MD): -0.915, 95 % Confidence interval (CI) -1.580 to -0.250, p < 0.01), 60 (MD: -1.122, 95 % CI -1.664 to -0.581, p < 0.001) and 90 days (MD: -2.226, 95 % CI -3.059 to -1.393, p < 0.001); as well as the area (mV.ms) after 30 (MD: -3.19, 95 % CI -5.94 to -0.44, p < 0.05), 60 (MD: -3.94, 95 % CI -6.24 to -1.64, p < 0.001) and 90 days (MD: -8.64, 95 % CI -12.08 to -5.21, p < 0.001). Transient differences were observed in latency and duration at 60 days. The progressive changes in phrenic nerve CMAP observed during DM suggest a decrement in axonal function rather than substantial demyelination.

UI MeSH Term Description Entries
D009132 Muscles Contractile tissue that produces movement in animals. Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D009431 Neural Conduction The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus. Nerve Conduction,Conduction, Nerve,Conduction, Neural,Conductions, Nerve,Conductions, Neural,Nerve Conductions,Neural Conductions
D010791 Phrenic Nerve The motor nerve of the diaphragm. The phrenic nerve fibers originate in the cervical spinal column (mostly C4) and travel through the cervical plexus to the diaphragm. Nerve, Phrenic,Nerves, Phrenic,Phrenic Nerves
D003921 Diabetes Mellitus, Experimental Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY. Alloxan Diabetes,Streptozocin Diabetes,Streptozotocin Diabetes,Experimental Diabetes Mellitus,Diabete, Streptozocin,Diabetes, Alloxan,Diabetes, Streptozocin,Diabetes, Streptozotocin,Streptozocin Diabete
D000200 Action Potentials Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli. Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013311 Streptozocin An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals. Streptozotocin,2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose,Streptozotocine,Zanosar
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

Marcelo C Ferrari, and João V Peixoto, and Rosalvo H Fogaça, and Fernando A Dias
December 2009, Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology,
Marcelo C Ferrari, and João V Peixoto, and Rosalvo H Fogaça, and Fernando A Dias
January 2023, Frontiers in neurology,
Marcelo C Ferrari, and João V Peixoto, and Rosalvo H Fogaça, and Fernando A Dias
September 2017, Biochemical and biophysical research communications,
Marcelo C Ferrari, and João V Peixoto, and Rosalvo H Fogaça, and Fernando A Dias
July 1977, The Journal of physiology,
Marcelo C Ferrari, and João V Peixoto, and Rosalvo H Fogaça, and Fernando A Dias
March 2006, Journal of neuroscience methods,
Marcelo C Ferrari, and João V Peixoto, and Rosalvo H Fogaça, and Fernando A Dias
March 1991, The Anatomical record,
Marcelo C Ferrari, and João V Peixoto, and Rosalvo H Fogaça, and Fernando A Dias
December 2010, Journal of diabetes,
Marcelo C Ferrari, and João V Peixoto, and Rosalvo H Fogaça, and Fernando A Dias
January 2000, Cell biology international,
Marcelo C Ferrari, and João V Peixoto, and Rosalvo H Fogaça, and Fernando A Dias
January 2008, Journal of brachial plexus and peripheral nerve injury,
Marcelo C Ferrari, and João V Peixoto, and Rosalvo H Fogaça, and Fernando A Dias
May 1989, The American journal of physiology,
Copied contents to your clipboard!