Biomaterial Database

Luminal and plasma glucose concentrations on intestinal fluid absorption and lymph flow. 1987

J S Lee

The effect of luminal (GL) and plasma (GP) glucose concentration on intestinal fluid absorption and lymph flow in the rat was studied. When GL was zero, fluid absorption rate (JV), total lymph flow, and "excess lymph flow" (JLe) during absorption from Krebs-Ringer solution was 155 +/- 16, 30 +/- 4, and 11 +/- 4 microliters X cm-1 X h-1, respectively, and JLe accounted for 7% of JV. JLe was the difference between total lymph flow and basal (nonabsorptive) lymph flow (JLb). In the presence of 28 mM glucose, JV and JLe increased by 37% to 212 +/- 22 and by 318% to 46 +/- 6 microliter X cm-1 X h-1, respectively. There was no further increase of either parameter when GL was 56 or 100 mM. When GL was zero and GP was increased to 43-64 mM during intravenous infusion of hypertonic glucose solution (2.78 M), JV and JLe increased by 32-35 and 313-380%, respectively, compared with that when GP was normal (11-14 mM). When GL was 28 mM and GP was 56 mM, a maximal rate of JV and JLe was obtained, and JLe accounted for 43 +/- 7% of JV. During infusion of hypertonic NaCl solution (1.54 M), JV decreased with little change in JLe. Furthermore, during infusion of either NaCl or glucose solution, the increase of plasma osmolarity resulted in approximately 100% increase of JLb. The results demonstrate that either GL, or GP, or both, increased JV and especially increased JLe.(ABSTRACT TRUNCATED AT 250 WORDS)

UI	MeSH Term	Description	Entries
D007408	Intestinal Absorption	Uptake of substances through the lining of the INTESTINES.	Absorption, Intestinal
D008196	Lymph	The interstitial fluid that is in the LYMPHATIC SYSTEM.	Lymphs
D008208	Lymphatic System	A system of organs and tissues that process and transport immune cells and LYMPH.	Lymphatic Systems
D008297	Male		Males
D001786	Blood Glucose	Glucose in blood.	Blood Sugar,Glucose, Blood,Sugar, Blood
D004231	Diuresis	An increase in the excretion of URINE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Diureses
D005947	Glucose	A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.	Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012462	Saline Solution, Hypertonic	Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).	Hypertonic Saline Solution,Hypertonic Solution, Saline,Sodium Chloride Solution, Hypertonic,Hypertonic Saline Solutions,Hypertonic Solutions, Saline,Saline Solutions, Hypertonic,Sodium Chloride Solutions, Hypertonic,Saline Hypertonic Solution,Saline Hypertonic Solutions,Solution, Hypertonic Saline,Solution, Saline Hypertonic,Solutions, Hypertonic Saline,Solutions, Saline Hypertonic
D014882	Water-Electrolyte Balance	The balance of fluid in the BODY FLUID COMPARTMENTS; total BODY WATER; BLOOD VOLUME; EXTRACELLULAR SPACE; INTRACELLULAR SPACE, maintained by processes in the body that regulate the intake and excretion of WATER and ELECTROLYTES, particularly SODIUM and POTASSIUM.	Fluid Balance,Electrolyte Balance,Balance, Electrolyte,Balance, Fluid,Balance, Water-Electrolyte,Water Electrolyte Balance